BDBM141409 US10668051, Compound Example 49::US8921364, 49

SMILES: FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2c(Cl)cncc2Cl)cc1

InChI Key: InChIKey=VFULESSGOQEDRW-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141409   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141409 (US10668051, Compound Example 49 | US8921364, 49) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2c(Cl)cncc2Cl)cc1 Show InChI InChI=1S/C19H13Cl2F3N4O/c20-13-8-25-9-14(21)17(13)18(29)26-11-3-5-12(6-4-11)28-15(10-1-2-10)7-16(27-28)19(22,23)24/h3-10H,1-2H2,(H,26,29)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	65.5	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141409 (US10668051, Compound Example 49 | US8921364, 49) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2c(Cl)cncc2Cl)cc1 Show InChI InChI=1S/C19H13Cl2F3N4O/c20-13-8-25-9-14(21)17(13)18(29)26-11-3-5-12(6-4-11)28-15(10-1-2-10)7-16(27-28)19(22,23)24/h3-10H,1-2H2,(H,26,29)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	65.5	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair