BDBM141421 US10668051, Compound Example 78::US8921364, 78

SMILES: Cc1ncsc1NC(=O)c1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F

InChI Key: InChIKey=KFLALJIMRGRRSE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141421   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141421 (US10668051, Compound Example 78 | US8921364, 78) Show SMILES Cc1ncsc1NC(=O)c1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H15F3N4OS/c1-10-17(27-9-22-10)23-16(26)12-4-6-13(7-5-12)25-14(11-2-3-11)8-15(24-25)18(19,20)21/h4-9,11H,2-3H2,1H3,(H,23,26)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.1	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium (CRAC) (Homo sapiens (Human))	BDBM141421 (US10668051, Compound Example 78 | US8921364, 78) Show SMILES Cc1ncsc1NC(=O)c1ccc(cc1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H15F3N4OS/c1-10-17(27-9-22-10)23-16(26)12-4-6-13(7-5-12)25-14(11-2-3-11)8-15(24-25)18(19,20)21/h4-9,11H,2-3H2,1H3,(H,23,26)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	34.1	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair