BDBM141425 US10668051, Compound Example 83::US8921364, 83

SMILES: Cc1ncsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F

InChI Key: InChIKey=XCTONGNRTZPQBT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141425   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141425 (US10668051, Compound Example 83 | US8921364, 83) Show SMILES Cc1ncsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H14F4N4OS/c1-9-16(28-8-23-9)17(27)24-11-4-5-13(12(19)6-11)26-14(10-2-3-10)7-15(25-26)18(20,21)22/h4-8,10H,2-3H2,1H3,(H,24,27)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.2	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium (CRAC) (Homo sapiens (Human))	BDBM141425 (US10668051, Compound Example 83 | US8921364, 83) Show SMILES Cc1ncsc1C(=O)Nc1ccc(c(F)c1)-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C18H14F4N4OS/c1-9-16(28-8-23-9)17(27)24-11-4-5-13(12(19)6-11)26-14(10-2-3-10)7-15(25-26)18(20,21)22/h4-8,10H,2-3H2,1H3,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48.2	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair