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SMILES: Fc1cccc(C(=O)Nc2ccc(c(F)c2)-n2nc(cc2C2CC2)C(F)(F)F)c1F

InChI Key: InChIKey=UAQNSPWVOORBLB-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141428   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141428 (US10668051, Compound Example 87 | US8921364, 87) Show SMILES Fc1cccc(C(=O)Nc2ccc(c(F)c2)-n2nc(cc2C2CC2)C(F)(F)F)c1F Show InChI InChI=1S/C20H13F6N3O/c21-13-3-1-2-12(18(13)23)19(30)27-11-6-7-15(14(22)8-11)29-16(10-4-5-10)9-17(28-29)20(24,25)26/h1-3,6-10H,4-5H2,(H,27,30)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141428 (US10668051, Compound Example 87 | US8921364, 87) Show SMILES Fc1cccc(C(=O)Nc2ccc(c(F)c2)-n2nc(cc2C2CC2)C(F)(F)F)c1F Show InChI InChI=1S/C20H13F6N3O/c21-13-3-1-2-12(18(13)23)19(30)27-11-6-7-15(14(22)8-11)29-16(10-4-5-10)9-17(28-29)20(24,25)26/h1-3,6-10H,4-5H2,(H,27,30)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32.6	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair