BDBM141431 US10668051, Compound Example 90::US8921364, 90

SMILES: Fc1cc(NC(=O)c2ccncc2)ccc1-n1nc(cc1C1CC1)C(F)(F)F

InChI Key: InChIKey=AVNNWXCNOLKWDE-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141431   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel (Homo sapiens (Human))	BDBM141431 (US10668051, Compound Example 90 | US8921364, 90) Show SMILES Fc1cc(NC(=O)c2ccncc2)ccc1-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H14F4N4O/c20-14-9-13(25-18(28)12-5-7-24-8-6-12)3-4-15(14)27-16(11-1-2-11)10-17(26-27)19(21,22)23/h3-11H,1-2H2,(H,25,28)	KEGG UniProtKB/SwissProt UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	232	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
Calcium release-activated calcium (CRAC) (Homo sapiens (Human))	BDBM141431 (US10668051, Compound Example 90 | US8921364, 90) Show SMILES Fc1cc(NC(=O)c2ccncc2)ccc1-n1nc(cc1C1CC1)C(F)(F)F Show InChI InChI=1S/C19H14F4N4O/c20-14-9-13(25-18(28)12-5-7-24-8-6-12)3-4-15(14)27-16(11-1-2-11)10-17(26-27)19(21,22)23/h3-11H,1-2H2,(H,25,28)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	232	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair