BDBM141443 US10668051, Compound Example 113::US8921364, 113

SMILES: FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2ccncc2)cn1

InChI Key: InChIKey=CWFWVONQCHIWTH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 141443   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Calcium release-activated calcium channel protein 1 (Homo sapiens (Human))	BDBM141443 (US10668051, Compound Example 113 | US8921364, 113) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2ccncc2)cn1 Show InChI InChI=1S/C18H14F3N5O/c19-18(20,21)15-9-14(11-1-2-11)26(25-15)16-4-3-13(10-23-16)24-17(27)12-5-7-22-8-6-12/h3-11H,1-2H2,(H,24,27)	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	62.6	n/a	n/a	n/a	n/a	n/a	n/a
RHIZEN PHARMACEUTICALS SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat #T9033) induced endoplasmic calcium release in Jurkat cells, (see Yasur...				US Patent US10668051 (2020)
					More data for this Ligand-Target Pair
EF-hand calcium-binding domain-containing protein 4B (Homo sapiens (Human))	BDBM141443 (US10668051, Compound Example 113 | US8921364, 113) Show SMILES FC(F)(F)c1cc(C2CC2)n(n1)-c1ccc(NC(=O)c2ccncc2)cn1 Show InChI InChI=1S/C18H14F3N5O/c19-18(20,21)15-9-14(11-1-2-11)26(25-15)16-4-3-13(10-23-16)24-17(27)12-5-7-22-8-6-12/h3-11H,1-2H2,(H,24,27)	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	62.6	n/a	n/a	n/a	n/a	n/a	37
Rhizen Pharmaceuticals SA US Patent					Assay Description Inhibition of CRAC channels was determined following thapsigargin (Sigma, Cat # T9033) induced endoplasmic calcium release in Jurkat cells. (see Yasu...				US Patent US8921364 (2014) BindingDB Entry DOI: 10.7270/Q2N58K3N
					More data for this Ligand-Target Pair