BDBM14156 3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-methylbenzamide::APC-10484::CHEMBL61327

SMILES: Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N

InChI Key: InChIKey=LTXLJGIDFWWEQI-UHFFFAOYSA-N

Data: 11 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 14156   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM14156 (3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...) Show SMILES Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N Show InChI InChI=1S/C15H14BrN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	77	-9.60	n/a	n/a	n/a	n/a	n/a	7.4	22
Axys Pharmaceutical					Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...				Chem Biol 8: 1107-21 (2001) Article DOI: 10.1016/S1074-5521(01)00084-9 BindingDB Entry DOI: 10.7270/Q2S75DKN
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM14156 (3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...) Show SMILES Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N Show InChI InChI=1S/C15H14BrN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celera Curated by ChEMBL					Assay Description Inhibition of urokinase-type plasminogen activator (microPa)				Bioorg Med Chem Lett 12: 2023-6 (2002) BindingDB Entry DOI: 10.7270/Q2ZG6RK4
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM14156 (3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...) Show SMILES Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N Show InChI InChI=1S/C15H14BrN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceutical					Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...				Chem Biol 8: 1107-21 (2001) Article DOI: 10.1016/S1074-5521(01)00084-9 BindingDB Entry DOI: 10.7270/Q2S75DKN
					More data for this Ligand-Target Pair
Trypsin (Bos taurus (bovine))	BDBM14156 (3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...) Show SMILES Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N Show InChI InChI=1S/C15H14BrN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceutical					Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...				Chem Biol 8: 1107-21 (2001) Article DOI: 10.1016/S1074-5521(01)00084-9 BindingDB Entry DOI: 10.7270/Q2S75DKN
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM14156 (3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...) Show SMILES Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N Show InChI InChI=1S/C15H14BrN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	280	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celera Curated by ChEMBL					Assay Description Inhibition of thrombin				Bioorg Med Chem Lett 12: 2023-6 (2002) BindingDB Entry DOI: 10.7270/Q2ZG6RK4
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM14156 (3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...) Show SMILES Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N Show InChI InChI=1S/C15H14BrN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceutical					Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...				Chem Biol 8: 1107-21 (2001) Article DOI: 10.1016/S1074-5521(01)00084-9 BindingDB Entry DOI: 10.7270/Q2S75DKN
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM14156 (3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...) Show SMILES Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N Show InChI InChI=1S/C15H14BrN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	360	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celera Curated by ChEMBL					Assay Description Activation of plasminogen				Bioorg Med Chem Lett 12: 2023-6 (2002) BindingDB Entry DOI: 10.7270/Q2ZG6RK4
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM14156 (3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...) Show SMILES Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N Show InChI InChI=1S/C15H14BrN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	410	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceutical					Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...				Chem Biol 8: 1107-21 (2001) Article DOI: 10.1016/S1074-5521(01)00084-9 BindingDB Entry DOI: 10.7270/Q2S75DKN
					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM14156 (3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...) Show SMILES Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N Show InChI InChI=1S/C15H14BrN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	440	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celera Curated by ChEMBL					Assay Description Inhibition of coagulation factor X				Bioorg Med Chem Lett 12: 2023-6 (2002) BindingDB Entry DOI: 10.7270/Q2ZG6RK4
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM14156 (3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...) Show SMILES Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N Show InChI InChI=1S/C15H14BrN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Celera Curated by ChEMBL					Assay Description Inhibition of plasmin				Bioorg Med Chem Lett 12: 2023-6 (2002) BindingDB Entry DOI: 10.7270/Q2ZG6RK4
					More data for this Ligand-Target Pair
Plasminogen (Homo sapiens (Human))	BDBM14156 (3-bromo-N-(4-carbamimidoylphenyl)-2-hydroxy-5-meth...) Show SMILES Cc1cc(Br)c(O)c(c1)C(=O)Nc1ccc(cc1)C(N)=N Show InChI InChI=1S/C15H14BrN3O2/c1-8-6-11(13(20)12(16)7-8)15(21)19-10-4-2-9(3-5-10)14(17)18/h2-7,20H,1H3,(H3,17,18)(H,19,21)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Axys Pharmaceutical					Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...				Chem Biol 8: 1107-21 (2001) Article DOI: 10.1016/S1074-5521(01)00084-9 BindingDB Entry DOI: 10.7270/Q2S75DKN
					More data for this Ligand-Target Pair