null

SMILES: NC(=[NH2+])c1cc2cccnc2s1

InChI Key: InChIKey=GZEJMYFXZMUAEC-UHFFFAOYSA-O

PDB links: 3 PDB IDs match this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14171   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tryptase beta-2 (Homo sapiens (Human))	BDBM14171 (APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...) Show SMILES NC(=[NH2+])c1cc2cccnc2s1 Show InChI InChI=1S/C8H7N3S/c9-7(10)6-4-5-2-1-3-11-8(5)12-6/h1-4H,(H3,9,10)/p+1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	3.40E+4	-6.03	n/a	n/a	n/a	n/a	n/a	7.4	22
Axys Pharmaceutical					Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...				Chem Biol 7: 299-312 (2000) Article DOI: 10.1016/S1074-5521(00)00104-6 BindingDB Entry DOI: 10.7270/Q2NG4NWC
					More data for this Ligand-Target Pair
Urokinase-type plasminogen activator (Homo sapiens (Human))	BDBM14171 (APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...) Show SMILES NC(=[NH2+])c1cc2cccnc2s1 Show InChI InChI=1S/C8H7N3S/c9-7(10)6-4-5-2-1-3-11-8(5)12-6/h1-4H,(H3,9,10)/p+1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	MMDB PDB Article PubMed	6.30E+4	-5.67	n/a	n/a	n/a	n/a	n/a	7.4	22
Axys Pharmaceutical					Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...				Chem Biol 7: 299-312 (2000) Article DOI: 10.1016/S1074-5521(00)00104-6 BindingDB Entry DOI: 10.7270/Q2NG4NWC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Serine protease 1 (Bos taurus (bovine))	BDBM14171 (APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...) Show SMILES NC(=[NH2+])c1cc2cccnc2s1 Show InChI InChI=1S/C8H7N3S/c9-7(10)6-4-5-2-1-3-11-8(5)12-6/h1-4H,(H3,9,10)/p+1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	DrugBank PDB Article PubMed	8.00E+4	-5.53	n/a	n/a	n/a	n/a	n/a	7.4	22
Axys Pharmaceutical					Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...				Chem Biol 7: 299-312 (2000) Article DOI: 10.1016/S1074-5521(00)00104-6 BindingDB Entry DOI: 10.7270/Q2NG4NWC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Coagulation factor X (Homo sapiens (Human))	BDBM14171 (APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...) Show SMILES NC(=[NH2+])c1cc2cccnc2s1 Show InChI InChI=1S/C8H7N3S/c9-7(10)6-4-5-2-1-3-11-8(5)12-6/h1-4H,(H3,9,10)/p+1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	3.60E+5	-4.65	n/a	n/a	n/a	n/a	n/a	7.4	22
Axys Pharmaceutical					Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...				Chem Biol 7: 299-312 (2000) Article DOI: 10.1016/S1074-5521(00)00104-6 BindingDB Entry DOI: 10.7270/Q2NG4NWC
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM14171 (APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...) Show SMILES NC(=[NH2+])c1cc2cccnc2s1 Show InChI InChI=1S/C8H7N3S/c9-7(10)6-4-5-2-1-3-11-8(5)12-6/h1-4H,(H3,9,10)/p+1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	1.60E+6	-3.77	n/a	n/a	n/a	n/a	n/a	7.4	22
Axys Pharmaceutical					Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...				Chem Biol 7: 299-312 (2000) Article DOI: 10.1016/S1074-5521(00)00104-6 BindingDB Entry DOI: 10.7270/Q2NG4NWC
					More data for this Ligand-Target Pair
Tissue-type plasminogen activator (Homo sapiens (Human))	BDBM14171 (APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...) Show SMILES NC(=[NH2+])c1cc2cccnc2s1 Show InChI InChI=1S/C8H7N3S/c9-7(10)6-4-5-2-1-3-11-8(5)12-6/h1-4H,(H3,9,10)/p+1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem	Article PubMed	1.80E+6	-3.70	n/a	n/a	n/a	n/a	n/a	7.4	22
Axys Pharmaceutical					Assay Description Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...				Chem Biol 7: 299-312 (2000) Article DOI: 10.1016/S1074-5521(00)00104-6 BindingDB Entry DOI: 10.7270/Q2NG4NWC
					More data for this Ligand-Target Pair