BDBM141899 US8921421, L-257::hDDAH inhibitor, 2a
SMILES: COCCNC(=N)NCCC[C@H](N)C(O)=O
InChI Key: InChIKey=XMBSMMCPKFDGEO-ZETCQYMHSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (Homo sapiens (Human)) | BDBM141899 (US8921421, L-257 | hDDAH inhibitor, 2a) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 1.30E+4 | -6.93 | n/a | n/a | n/a | n/a | n/a | 7.4 | 37 |
Christian-Albrechts-University | Assay Description A colorimetric assay was carried out in 150 μL 50 mM potassium phosphate buffer pH 7.4 containing 4 μg of recombinant hDDAH-1 and varying c... | J Enzyme Inhib Med Chem 27: 24-8 (2012) Article DOI: 10.3109/14756366.2011.573480 BindingDB Entry DOI: 10.7270/Q24B3064 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (Homo sapiens (Human)) | BDBM141899 (US8921421, L-257 | hDDAH inhibitor, 2a) | PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Similars | PDB US Patent | 1.30E+4 | n/a | 2.90E+4 | n/a | n/a | n/a | n/a | 7.4 | n/a |
Christian-Albrechts-Universitaet Zu Kiel US Patent | Assay Description This assay was used to determine the inhibiting effect of the inhibitors in a concentration of 1 mM. A standard incubation mixture consisted of 75 ... | US Patent US8921421 (2014) BindingDB Entry DOI: 10.7270/Q2GH9GP9 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |