BDBM142236 US8933099, 2

SMILES: CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1

InChI Key: InChIKey=CDEGANXKDGRJLR-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 142236   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Fibroblast growth factor 2 (Homo sapiens (Human))	BDBM142236 (US8933099, 2) Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1 Show InChI InChI=1S/C30H33N5O4/c1-4-34-14-10-21(11-15-34)20-5-7-22(8-6-20)29(36)33-28-18-24(9-13-32-28)39-27-17-23-12-16-35(30(37)31-2)25(23)19-26(27)38-3/h5-9,12-13,16-19,21H,4,10-11,14-15H2,1-3H3,(H,31,37)(H,32,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	25
Eisai R&D Management Co., Ltd. US Patent					Assay Description In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR2 protein is measured.To each well of a flat b...				US Patent US8933099 (2015) BindingDB Entry DOI: 10.7270/Q28S4NMG
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 1 (Homo sapiens (Human))	BDBM142236 (US8933099, 2) Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1 Show InChI InChI=1S/C30H33N5O4/c1-4-34-14-10-21(11-15-34)20-5-7-22(8-6-20)29(36)33-28-18-24(9-13-32-28)39-27-17-23-12-16-35(30(37)31-2)25(23)19-26(27)38-3/h5-9,12-13,16-19,21H,4,10-11,14-15H2,1-3H3,(H,31,37)(H,32,33,36)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	10.1	n/a	n/a	n/a	n/a	n/a	25
Eisai R&D Management Co., Ltd. US Patent					Assay Description In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR1 protein is measured.To each well of a flat b...				US Patent US8933099 (2015) BindingDB Entry DOI: 10.7270/Q28S4NMG
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 4 (Homo sapiens (Human))	BDBM142236 (US8933099, 2) Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1 Show InChI InChI=1S/C30H33N5O4/c1-4-34-14-10-21(11-15-34)20-5-7-22(8-6-20)29(36)33-28-18-24(9-13-32-28)39-27-17-23-12-16-35(30(37)31-2)25(23)19-26(27)38-3/h5-9,12-13,16-19,21H,4,10-11,14-15H2,1-3H3,(H,31,37)(H,32,33,36)	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	651	n/a	n/a	n/a	n/a	n/a	25
Eisai R&D Management Co., Ltd. US Patent					Assay Description In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR4 protein is measured.To each well of a flat b...				US Patent US8933099 (2015) BindingDB Entry DOI: 10.7270/Q28S4NMG
					More data for this Ligand-Target Pair
Fibroblast growth factor receptor 3 (Homo sapiens (Human))	BDBM142236 (US8933099, 2) Show SMILES CCN1CCC(CC1)c1ccc(cc1)C(=O)Nc1cc(Oc2cc3ccn(C(=O)NC)c3cc2OC)ccn1 Show InChI InChI=1S/C30H33N5O4/c1-4-34-14-10-21(11-15-34)20-5-7-22(8-6-20)29(36)33-28-18-24(9-13-32-28)39-27-17-23-12-16-35(30(37)31-2)25(23)19-26(27)38-3/h5-9,12-13,16-19,21H,4,10-11,14-15H2,1-3H3,(H,31,37)(H,32,33,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7.90	n/a	n/a	n/a	n/a	n/a	25
Eisai R&D Management Co., Ltd. US Patent					Assay Description In this assay, the inhibitory activity of a test substance against the tyrosine kinase activity of FGFR3 protein is measured.To each well of a flat b...				US Patent US8933099 (2015) BindingDB Entry DOI: 10.7270/Q28S4NMG
					More data for this Ligand-Target Pair