BDBM142451 US8933224, 44
SMILES: Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nn(C)c(C3CC3)c2C1
InChI Key: InChIKey=SYRPJHKMGQGRQF-CQSZACIVSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM142451 (US8933224, 44) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.110 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pfizer Inc. US Patent | Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ... | US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat)) | BDBM142451 (US8933224, 44) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.102 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pfizer Inc. US Patent | Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ... | US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35 | |||||||||||
More data for this Ligand-Target Pair |