BDBM142544 US8933224, 137

SMILES: CCc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1

InChI Key: InChIKey=WGFZLXFAMITYML-OAHLLOKOSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 142544   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM142544 (US8933224, 137) Show SMILES CCc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r| Show InChI InChI=1S/C22H27N7O/c1-3-17-16-10-28(8-6-18(16)27-21(26-17)14-4-5-14)22-20-19(15-7-9-30-11-15)25-13(2)29(20)24-12-23-22/h12,14-15H,3-11H2,1-2H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0777	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat))	BDBM142544 (US8933224, 137) Show SMILES CCc1nc(nc2CCN(Cc12)c1ncnn2c(C)nc([C@@H]3CCOC3)c12)C1CC1 |r| Show InChI InChI=1S/C22H27N7O/c1-3-17-16-10-28(8-6-18(16)27-21(26-17)14-4-5-14)22-20-19(15-7-9-30-11-15)25-13(2)29(20)24-12-23-22/h12,14-15H,3-11H2,1-2H3/t15-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.0950	n/a	n/a	n/a	n/a	7.5	n/a
Pfizer Inc. US Patent					Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ...				US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35
					More data for this Ligand-Target Pair