BDBM142550 US8933224, 143::US8933224, 144
SMILES: Cc1nc([C@@H]2CCOC2)c2c(ncnn12)N1CCc2nc(C3CC3)n(C)c(=O)c2C1
InChI Key: InChIKey=PWBLEQJWHKHJEQ-CQSZACIVSA-N
Data: 3 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat)) | BDBM142550 (US8933224, 143 | US8933224, 144) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.106 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pfizer Inc. US Patent | Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ... | US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM142550 (US8933224, 143 | US8933224, 144) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.219 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pfizer Inc. US Patent | Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ... | US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 10 (PDE10A) (Rattus norvegicus (rat)) | BDBM142550 (US8933224, 143 | US8933224, 144) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 0.0837 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Pfizer Inc. US Patent | Assay Description The ability of a compound to inhibit PDE10 enzymatic activity can be demonstrated by any number of assays that are known in the art. The products of ... | US Patent US8933224 (2015) BindingDB Entry DOI: 10.7270/Q2WM1C35 | |||||||||||
More data for this Ligand-Target Pair |