BDBM142621 US8933228, 12

SMILES: COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C(C)C)c23)c2ccccc12)C(C)(C)C

InChI Key: InChIKey=URQAXVPGUSETSW-UHFFFAOYSA-N

Data: 4 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 142621   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM142621 (US8933228, 12) Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C(C)C)c23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C34H35N7O4/c1-20(2)40-30-27(17-18-35-31(30)38-33(40)43)45-26-16-15-25(23-9-7-8-10-24(23)26)36-32(42)37-29-19-28(34(3,4)5)39-41(29)21-11-13-22(44-6)14-12-21/h7-20H,1-6H3,(H,35,38,43)(H2,36,37,42)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
Respivert, Ltd. US Patent					Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...				US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase Src (Homo sapiens (Human))	BDBM142621 (US8933228, 12) Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C(C)C)c23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C34H35N7O4/c1-20(2)40-30-27(17-18-35-31(30)38-33(40)43)45-26-16-15-25(23-9-7-8-10-24(23)26)36-32(42)37-29-19-28(34(3,4)5)39-41(29)21-11-13-22(44-6)14-12-21/h7-20H,1-6H3,(H,35,38,43)(H2,36,37,42)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	12	n/a	n/a	n/a	n/a	n/a	n/a
Respivert, Ltd. US Patent					Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...				US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW
					More data for this Ligand-Target Pair
Tyrosine-protein kinase HCK (Homo sapiens (Human))	BDBM142621 (US8933228, 12) Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C(C)C)c23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C34H35N7O4/c1-20(2)40-30-27(17-18-35-31(30)38-33(40)43)45-26-16-15-25(23-9-7-8-10-24(23)26)36-32(42)37-29-19-28(34(3,4)5)39-41(29)21-11-13-22(44-6)14-12-21/h7-20H,1-6H3,(H,35,38,43)(H2,36,37,42)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
Respivert, Ltd. US Patent					Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...				US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 12 (Homo sapiens (Human))	BDBM142621 (US8933228, 12) Show SMILES COc1ccc(cc1)-n1nc(cc1NC(=O)Nc1ccc(Oc2ccnc3[nH]c(=O)n(C(C)C)c23)c2ccccc12)C(C)(C)C Show InChI InChI=1S/C34H35N7O4/c1-20(2)40-30-27(17-18-35-31(30)38-33(40)43)45-26-16-15-25(23-9-7-8-10-24(23)26)36-32(42)37-29-19-28(34(3,4)5)39-41(29)21-11-13-22(44-6)14-12-21/h7-20H,1-6H3,(H,35,38,43)(H2,36,37,42)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	495	n/a	n/a	n/a	n/a	n/a	n/a
Respivert, Ltd. US Patent					Assay Description The enzyme inhibitory activity of test compounds was determined by fluorescence resonance energy transfer (FRET) using synthetic peptides labelled wi...				US Patent US8933228 (2015) BindingDB Entry DOI: 10.7270/Q2RV0MDW
					More data for this Ligand-Target Pair