Found 75 hits for monomerid = 14363 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
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| n/a | n/a | n/a | n/a | 9.00E+3 | n/a | n/a | n/a | n/a |
Laboratories Glaxo Wellcome Centre de Recherches
Curated by ChEMBL
| Assay Description Compound was tested for inhibition of stimulation of rat aortic smooth muscle cells (RSMC) |
J Med Chem 39: 1635-44 (1996)
Article DOI: 10.1021/jm950812j BindingDB Entry DOI: 10.7270/Q2057F1T |
More data for this Ligand-Target Pair | |
cGMP-dependent 3',5'-cyclic phosphodiesterase
(Rattus norvegicus) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
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| n/a | n/a | 6.31E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of rat brain particulate cGMP phosphodiesterase |
J Med Chem 25: 1192-8 (1983)
BindingDB Entry DOI: 10.7270/Q21G0NFF |
More data for this Ligand-Target Pair | |
Alkaline phosphatase, germ cell type
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
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| n/a | n/a | 6.25E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description 50% inhibition of human placental alkaline phosphatase in the presence of 10 mM p-nitrophenyl phosphate as substrate |
J Med Chem 25: 742-5 (1982)
BindingDB Entry DOI: 10.7270/Q20G3MBH |
More data for this Ligand-Target Pair | |
Alkaline phosphatase, tissue-nonspecific isozyme
(Rattus norvegicus) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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| n/a | n/a | 1.75E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Concentration required for 50% inhibition of human leukocyte alkaline phosphatase in the presence of 10 mM p-nitrophenyl phosphate as substrate |
J Med Chem 25: 742-5 (1982)
BindingDB Entry DOI: 10.7270/Q20G3MBH |
More data for this Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
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| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of [Ca(2+)]/calmodulin dependent phosphodiesterase PDE 1 of human lung |
J Med Chem 28: 537-45 (1985)
BindingDB Entry DOI: 10.7270/Q2N58MXT |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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| n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
Corning Inc.
Curated by ChEMBL
| Assay Description Agonist activity at GPR35 in human HT-29 cells by dynamic mass redistribution assay |
Bioorg Med Chem Lett 22: 4148-52 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.057 BindingDB Entry DOI: 10.7270/Q2C53MW0 |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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| n/a | n/a | n/a | n/a | 6.20E+3 | n/a | n/a | n/a | n/a |
Corning Inc.
Curated by ChEMBL
| Assay Description Agonist activity at GPR35 in human U20S cells expressing beta-lactamase and Gal4-VP16 transcription factor assessed as beta arrestin translocation af... |
Bioorg Med Chem Lett 22: 4148-52 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.057 BindingDB Entry DOI: 10.7270/Q2C53MW0 |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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| n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist activity at GPR35 receptor in human HT-29 cells after 10 mins by dynamic mass redistribution assay |
ACS Med Chem Lett 3: 165-169 (2012)
Article DOI: 10.1021/ml2003058 BindingDB Entry DOI: 10.7270/Q2DB82W9 |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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| n/a | n/a | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Agonist activity at GPR35 receptor in human U2OS cells coexpressing Gal4-VP16-TEV assessed as beta arrestin translocation after 5 hrs by beta lactmas... |
ACS Med Chem Lett 3: 165-169 (2012)
Article DOI: 10.1021/ml2003058 BindingDB Entry DOI: 10.7270/Q2DB82W9 |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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| n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Desensitization of GPR35 receptor in human HT-29 cells assessed as inhibition of zaprinast-induced dynamic mass redistribution after 10 mins |
ACS Med Chem Lett 3: 165-169 (2012)
Article DOI: 10.1021/ml2003058 BindingDB Entry DOI: 10.7270/Q2DB82W9 |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Bos taurus) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
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| n/a | n/a | 600 | n/a | n/a | n/a | n/a | n/a | n/a |
Youai Co., Ltd
Curated by ChEMBL
| Assay Description Inhibition of bovine platelet PDE5 |
Bioorg Med Chem Lett 22: 3983-7 (2012)
Article DOI: 10.1016/j.bmcl.2012.04.094 BindingDB Entry DOI: 10.7270/Q2RR209T |
More data for this Ligand-Target Pair | |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A/1B/1C
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
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| n/a | n/a | 6.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of phosphodiesterase (PDE I). |
Bioorg Med Chem Lett 7: 89-94 (1997)
Article DOI: 10.1016/S0960-894X(96)00578-1 BindingDB Entry DOI: 10.7270/Q2XP74X9 |
More data for this Ligand-Target Pair | |
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
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| n/a | n/a | 1.33E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vitro inhibition of phosphodiesterase (PDE III). |
Bioorg Med Chem Lett 7: 89-94 (1997)
Article DOI: 10.1016/S0960-894X(96)00578-1 BindingDB Entry DOI: 10.7270/Q2XP74X9 |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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| n/a | n/a | n/a | n/a | 3.52E+3 | n/a | n/a | n/a | n/a |
Dalian Institute of Chemical Physics
Curated by ChEMBL
| Assay Description Agonist activity at TEV protease cleavage site linked GAL4-VP16-fused GPR35 in human Tango GPR35-bla U2OS cells assessed as induction of TEV protease... |
J Med Chem 60: 362-372 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01431 BindingDB Entry DOI: 10.7270/Q2J67KC8 |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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| n/a | n/a | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a |
Chinese Academy of Sciences
Curated by ChEMBL
| Assay Description Agonist activity at human GPR35 assessed as induction of beta-arrestin recruitment |
ACS Med Chem Lett 9: 422-427 (2018)
Article DOI: 10.1021/acsmedchemlett.7b00510 BindingDB Entry DOI: 10.7270/Q2GB26K8 |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
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| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of PDE5 (unknown origin) |
J Med Chem 61: 6421-6467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00180 BindingDB Entry DOI: 10.7270/Q2DJ5J62 |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
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| n/a | n/a | 3.16E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of PDE5 (unknown origin) |
J Med Chem 61: 6421-6467 (2018)
Article DOI: 10.1021/acs.jmedchem.8b00180 BindingDB Entry DOI: 10.7270/Q2DJ5J62 |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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| n/a | n/a | n/a | n/a | 340 | n/a | n/a | n/a | n/a |
Dalian Institute of Chemical Physics
Curated by ChEMBL
| Assay Description Agonist activity at GPR35 in human HT-29 cells by DMR assay |
J Med Chem 60: 362-372 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01431 BindingDB Entry DOI: 10.7270/Q2J67KC8 |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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| n/a | n/a | n/a | n/a | 160 | n/a | n/a | n/a | n/a |
Dalian Institute of Chemical Physics
Curated by ChEMBL
| Assay Description Agonist activity at human GPR35 expressed in CHO-K1 cells by DMR assay |
J Med Chem 60: 362-372 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01431 BindingDB Entry DOI: 10.7270/Q2J67KC8 |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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| n/a | n/a | n/a | n/a | 4.20E+3 | n/a | n/a | n/a | n/a |
Dalian Institute of Chemical Physics
Curated by ChEMBL
| Assay Description Agonist activity at human GPR35 expressed in CHO-K1 cells after 90 mins by beta-arrestin 2 recruitment assay |
J Med Chem 60: 362-372 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01431 BindingDB Entry DOI: 10.7270/Q2J67KC8 |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Bos taurus) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
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| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ de Strasbourg
Curated by ChEMBL
| Assay Description Inhibition of bovine aortic smooth muscle PDE5 using cGMP as substrate incubated for 30 mins in presence of EGTA and [3H]cGMP by liquid scintillation... |
Eur J Med Chem 177: 269-290 (2019)
Article DOI: 10.1016/j.ejmech.2019.05.026 BindingDB Entry DOI: 10.7270/Q2C250W8 |
More data for this Ligand-Target Pair | |
cGMP-specific 3',5'-cyclic phosphodiesterase
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB MMDB
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| n/a | n/a | 6.52E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human recombinant PDE5A using cGMP as substrate incubated for 20 mins measured by Kinase Glo reagent based microplate reader assay |
Citation and Details
Article DOI: 10.1016/j.ejmech.2020.112854 BindingDB Entry DOI: 10.7270/Q2RJ4P6F |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
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| n/a | n/a | n/a | n/a | 340 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at human GPR35 receptor expressed in HT-29 cells assessed as dynamic mass redistribution response by DMR assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01624 BindingDB Entry DOI: 10.7270/Q2T72N8P |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 63 | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as dynamic mass redistribution response by DMR assay |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01624 BindingDB Entry DOI: 10.7270/Q2T72N8P |
More data for this Ligand-Target Pair | |
G-protein coupled receptor 35
(Homo sapiens (Human)) | BDBM14363
(3-(2-propoxyphenyl)-2,4,7,8,9-pentazabicyclo[4.3.0...)Show InChI InChI=1S/C13H13N5O2/c1-2-7-20-9-6-4-3-5-8(9)11-14-12-10(13(19)15-11)16-18-17-12/h3-6H,2,7H2,1H3,(H2,14,15,16,17,18,19) | PDB
KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| Purchase
PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Agonist activity at human GPR35 receptor expressed in CHO-K1 cells assessed as desensitization of zaprinast-induced DMR response preincubated for 1 h... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c01624 BindingDB Entry DOI: 10.7270/Q2T72N8P |
More data for this Ligand-Target Pair | |