BDBM14367 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3-methoxy-benzyloxy)-1-methyl-ethyl]-3H-purin-6-ylamine::3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-8-{2-[(3-methoxyphenyl)methoxy]propan-2-yl}-3H-purin-6-amine::V11294 Analogue 5c

SMILES: COc1cccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)c1

InChI Key: InChIKey=TYIBVHZITAXGDO-UHFFFAOYSA-N

Data: 5 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14367   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM14367 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3-meth...) Show SMILES COc1cccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)c1 Show InChI InChI=1S/C29H35N5O4/c1-29(2,37-17-20-8-7-11-22(14-20)35-3)28-32-25-26(30)31-18-34(27(25)33-28)16-19-12-13-23(36-4)24(15-19)38-21-9-5-6-10-21/h7-8,11-15,18,21H,5-6,9-10,16-17,30H2,1-4H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	5.10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM14367 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3-meth...) Show SMILES COc1cccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)c1 Show InChI InChI=1S/C29H35N5O4/c1-29(2,37-17-20-8-7-11-22(14-20)35-3)28-32-25-26(30)31-18-34(27(25)33-28)16-19-12-13-23(36-4)24(15-19)38-21-9-5-6-10-21/h7-8,11-15,18,21H,5-6,9-10,16-17,30H2,1-4H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	6	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human))	BDBM14367 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3-meth...) Show SMILES COc1cccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)c1 Show InChI InChI=1S/C29H35N5O4/c1-29(2,37-17-20-8-7-11-22(14-20)35-3)28-32-25-26(30)31-18-34(27(25)33-28)16-19-12-13-23(36-4)24(15-19)38-21-9-5-6-10-21/h7-8,11-15,18,21H,5-6,9-10,16-17,30H2,1-4H3	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	13	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM14367 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3-meth...) Show SMILES COc1cccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)c1 Show InChI InChI=1S/C29H35N5O4/c1-29(2,37-17-20-8-7-11-22(14-20)35-3)28-32-25-26(30)31-18-34(27(25)33-28)16-19-12-13-23(36-4)24(15-19)38-21-9-5-6-10-21/h7-8,11-15,18,21H,5-6,9-10,16-17,30H2,1-4H3	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	175	-9.12	n/a	n/a	n/a	n/a	n/a	8.0	22
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human))	BDBM14367 (3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3-meth...) Show SMILES COc1cccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)c1 Show InChI InChI=1S/C29H35N5O4/c1-29(2,37-17-20-8-7-11-22(14-20)35-3)28-32-25-26(30)31-18-34(27(25)33-28)16-19-12-13-23(36-4)24(15-19)38-21-9-5-6-10-21/h7-8,11-15,18,21H,5-6,9-10,16-17,30H2,1-4H3	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	296	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Purdue Pharma LP					Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...				J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0
					More data for this Ligand-Target Pair