BDBM14373 (2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-8-{2-[(3,4-dimethoxyphenyl)methoxy]propan-2-yl}-3H-purin-6-amine::3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(3,4-dimethoxy-benzyloxy)-1-methyl-ethyl]-3Hpurin-6-ylamine Fumarate::V11294 Analogue 5i
SMILES: COc1ccc(COC(C)(C)c2nc3c(N)ncn(Cc4ccc(OC)c(OC5CCCC5)c4)c3n2)cc1OC
InChI Key: InChIKey=OUMOQJLQYWKYEI-UHFFFAOYSA-N
Data: 5 KI
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM14373 ((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 7.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue Pharma LP | Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu... | J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM14373 ((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 15 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue Pharma LP | Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu... | J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM14373 ((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 42.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue Pharma LP | Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu... | J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human)) | BDBM14373 ((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 405 | -8.63 | n/a | n/a | n/a | n/a | n/a | 8.0 | 22 |
Purdue Pharma LP | Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu... | J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4D (Homo sapiens (Human)) | BDBM14373 ((2E)-but-2-enedioic acid; 3-{[3-(cyclopentyloxy)-4...) | PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | 2.64E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Purdue Pharma LP | Assay Description PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu... | J Med Chem 48: 1237-43 (2005) Article DOI: 10.1021/jm030603w BindingDB Entry DOI: 10.7270/Q2GT5KF0 | |||||||||||
More data for this Ligand-Target Pair |