BDBM14396 5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one::Sildenafil 5-methyl ketone analogue 56
SMILES: CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)C(=O)CN1CCOCC1
InChI Key: InChIKey=AANJEOKXWMXQIE-UHFFFAOYSA-N
Data: 2 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phosphodiesterase Type 6 (PDE6) (Canis lupus familiaris (Dog)) | BDBM14396 (5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-... | J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM14396 (5-{2-ethoxy-5-[2-(morpholin-4-yl)acetyl]phenyl}-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.70 | n/a | n/a | n/a | n/a | 7.4 | 30 |
Pfizer | Assay Description PDE5 or PDE6 catalytic activity was monitored by measuring the hydrolysis of [3H]-cGMP to [3H]-GMP using a scintillation proximity assay (SPA). [3H]-... | J Med Chem 49: 3581-94 (2006) Article DOI: 10.1021/jm060113e BindingDB Entry DOI: 10.7270/Q2C24TP4 | |||||||||||
More data for this Ligand-Target Pair |