null

SMILES: CN1CCN(CC1)C1CCN(CC1)c1ccc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c(Cl)nc2C(N)=O)cc1C

InChI Key: InChIKey=OZHDGGPIVQKPDI-XYWHTSSQSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 144331   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Proto-oncogene tyrosine-protein kinase receptor Ret (Homo sapiens (Human))	BDBM144331 (US8969336, 575) Show SMILES CN1CCN(CC1)C1CCN(CC1)c1ccc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c(Cl)nc2C(N)=O)cc1C |r,wU:25.27,wD:22.23,(-12.05,4.35,;-10.72,3.58,;-9.34,4.32,;-8,3.55,;-8,2.01,;-9.34,1.24,;-10.67,2.01,;-6.67,1.24,;-6.67,-.3,;-5.33,-1.07,;-4,-.3,;-4,1.24,;-5.33,2.01,;-2.67,-1.07,;-1.33,-.3,;,-1.07,;,-2.61,;1.33,-3.38,;2.67,-2.61,;4,-3.38,;5.33,-2.61,;6.67,-3.38,;8,-2.61,;9.34,-3.38,;10.67,-2.61,;10.67,-1.07,;12,-.3,;9.34,-.3,;8,-1.07,;5.33,-1.07,;6.67,-.3,;4,-.3,;2.67,-1.07,;1.9,.27,;2.67,1.6,;.36,.27,;-1.33,-3.38,;-2.72,-2.63,;-4.05,-3.4,)| Show InChI InChI=1S/C28H41ClN8O2/c1-18-17-20(5-8-23(18)37-11-9-21(10-12-37)36-15-13-35(2)14-16-36)32-27-24(26(30)39)33-25(29)28(34-27)31-19-3-6-22(38)7-4-19/h5,8,17,19,21-22,38H,3-4,6-7,9-16H2,1-2H3,(H2,30,39)(H2,31,32,34)/t19-,22-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.30	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd. US Patent					Assay Description A partial protein of only a kinase domain of RET protein was purchased from Carna Biosciences Inc., Japan. The phosphorylation activity toward a pept...				US Patent US8969336 (2015) BindingDB Entry DOI: 10.7270/Q2NV9GZW
					More data for this Ligand-Target Pair
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM144331 (US8969336, 575) Show SMILES CN1CCN(CC1)C1CCN(CC1)c1ccc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c(Cl)nc2C(N)=O)cc1C |r,wU:25.27,wD:22.23,(-12.05,4.35,;-10.72,3.58,;-9.34,4.32,;-8,3.55,;-8,2.01,;-9.34,1.24,;-10.67,2.01,;-6.67,1.24,;-6.67,-.3,;-5.33,-1.07,;-4,-.3,;-4,1.24,;-5.33,2.01,;-2.67,-1.07,;-1.33,-.3,;,-1.07,;,-2.61,;1.33,-3.38,;2.67,-2.61,;4,-3.38,;5.33,-2.61,;6.67,-3.38,;8,-2.61,;9.34,-3.38,;10.67,-2.61,;10.67,-1.07,;12,-.3,;9.34,-.3,;8,-1.07,;5.33,-1.07,;6.67,-.3,;4,-.3,;2.67,-1.07,;1.9,.27,;2.67,1.6,;.36,.27,;-1.33,-3.38,;-2.72,-2.63,;-4.05,-3.4,)| Show InChI InChI=1S/C28H41ClN8O2/c1-18-17-20(5-8-23(18)37-11-9-21(10-12-37)36-15-13-35(2)14-16-36)32-27-24(26(30)39)33-25(29)28(34-27)31-19-3-6-22(38)7-4-19/h5,8,17,19,21-22,38H,3-4,6-7,9-16H2,1-2H3,(H2,30,39)(H2,31,32,34)/t19-,22-	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	0.720	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd. US Patent					Assay Description A partial protein of only a kinase domain of FLT3 protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Examp...				US Patent US8969336 (2015) BindingDB Entry DOI: 10.7270/Q2NV9GZW
					More data for this Ligand-Target Pair
Proto-oncogene tyrosine-protein kinase ROS (Homo sapiens (Human))	BDBM144331 (US8969336, 575) Show SMILES CN1CCN(CC1)C1CCN(CC1)c1ccc(Nc2nc(N[C@H]3CC[C@H](O)CC3)c(Cl)nc2C(N)=O)cc1C |r,wU:25.27,wD:22.23,(-12.05,4.35,;-10.72,3.58,;-9.34,4.32,;-8,3.55,;-8,2.01,;-9.34,1.24,;-10.67,2.01,;-6.67,1.24,;-6.67,-.3,;-5.33,-1.07,;-4,-.3,;-4,1.24,;-5.33,2.01,;-2.67,-1.07,;-1.33,-.3,;,-1.07,;,-2.61,;1.33,-3.38,;2.67,-2.61,;4,-3.38,;5.33,-2.61,;6.67,-3.38,;8,-2.61,;9.34,-3.38,;10.67,-2.61,;10.67,-1.07,;12,-.3,;9.34,-.3,;8,-1.07,;5.33,-1.07,;6.67,-.3,;4,-.3,;2.67,-1.07,;1.9,.27,;2.67,1.6,;.36,.27,;-1.33,-3.38,;-2.72,-2.63,;-4.05,-3.4,)| Show InChI InChI=1S/C28H41ClN8O2/c1-18-17-20(5-8-23(18)37-11-9-21(10-12-37)36-15-13-35(2)14-16-36)32-27-24(26(30)39)33-25(29)28(34-27)31-19-3-6-22(38)7-4-19/h5,8,17,19,21-22,38H,3-4,6-7,9-16H2,1-2H3,(H2,30,39)(H2,31,32,34)/t19-,22-	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.60	n/a	n/a	n/a	n/a	n/a	n/a
Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd. US Patent					Assay Description A partial protein of only a kinase domain of ROS protein was purchased from Carna Biosciences Inc., Japan, and tests were conducted as in Test Exampl...				US Patent US8969336 (2015) BindingDB Entry DOI: 10.7270/Q2NV9GZW
					More data for this Ligand-Target Pair