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BDBM144469 US8969568, 20

SMILES: CC[C@@H](Oc1nc(cc2ncccc12)-c1cc(OC)c(OCCN2CCOCC2)c(OC)c1)[C@H]1CNC(=O)C1

InChI Key: InChIKey=AVGXUNVNNIZQOV-YCYISBKGNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144469   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144469
PNG
(US8969568, 20)
Show SMILES CC[C@@H](Oc1nc(cc2ncccc12)-c1cc(OC)c(OCCN2CCOCC2)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C29H36N4O6/c1-4-24(20-16-27(34)31-18-20)39-29-21-6-5-7-30-23(21)17-22(32-29)19-14-25(35-2)28(26(15-19)36-3)38-13-10-33-8-11-37-12-9-33/h5-7,14-15,17,20,24H,4,8-13,16,18H2,1-3H3,(H,31,34)/t20-,24-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.700n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair