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BDBM144489 US8969568, 41

SMILES: CC[C@@H](Oc1nc(cc2ncccc12)-c1cc(OC)c(OC)c(OC)c1)[C@H]1CNC(=O)C1

InChI Key: InChIKey=KDBBHCQXKQMERW-FPOITTPVNA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144489   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144489
PNG
(US8969568, 41)
Show SMILES CC[C@@H](Oc1nc(cc2ncccc12)-c1cc(OC)c(OC)c(OC)c1)[C@H]1CNC(=O)C1 |r|
Show InChI InChI=1/C24H27N3O5/c1-5-19(15-11-22(28)26-13-15)32-24-16-7-6-8-25-18(16)12-17(27-24)14-9-20(29-2)23(31-4)21(10-14)30-3/h6-10,12,15,19H,5,11,13H2,1-4H3,(H,26,28)/t15-,19-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.300n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair