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BDBM144498 US8969568, 50

SMILES: COC[C@H](C)Oc1ccc(cc1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1

InChI Key: InChIKey=XARXPQIZVKMTDO-REIYMHPCNA-N

Data: 1 IC50

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   Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144498   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144498
PNG
(US8969568, 50)
Show SMILES COC[C@H](C)Oc1ccc(cc1OC)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1/C24H27N3O5/c1-15(13-29-2)32-21-7-6-17(10-22(21)30-3)19-11-20-18(5-4-8-25-20)24(27-19)31-14-16-9-23(28)26-12-16/h4-8,10-11,15-16H,9,12-14H2,1-3H3,(H,26,28)/t15-,16+/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 2.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair