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BDBM144504 US8969568, 103::US8969568, 104::US8969568, 105::US8969568, 106::US8969568, 109::US8969568, 110::US8969568, 114::US8969568, 116::US8969568, 57

SMILES: Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1

InChI Key: InChIKey=LGLTUBADVDGOPY-UEQNJFAPNA-N

Data: 9 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 144504   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/s2
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n/an/a 13.7n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/s2
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n/an/a 4.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/s2
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n/an/a 2.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/s2
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n/an/a 5.10n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/s2
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n/an/a 7.40n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/s2
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n/an/a 20.4n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/s2
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n/an/a 4.70n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/s2
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n/an/a 17.8n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair
Tyrosine-protein kinase SYK


(Homo sapiens (Human))
BDBM144504
PNG
(US8969568, 103 | US8969568, 104 | US8969568, 105 |...)
Show SMILES Cc1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1/C14H15N3O2/c1-9-5-12-11(3-2-4-15-12)14(17-9)19-8-10-6-13(18)16-7-10/h2-5,10H,6-8H2,1H3,(H,16,18)/t10-/s2
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n/an/a 6.20n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...


US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair