BDBM144509 US8969568, 62

SMILES: COc1cc(ccc1O[C@H]1CCCOC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1

InChI Key: InChIKey=HXIHZWDMJDTXDW-AEFFLSMTSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144509   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase SYK (Homo sapiens (Human))	BDBM144509 (US8969568, 62) Show SMILES COc1cc(ccc1O[C@H]1CCCOC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r| Show InChI InChI=1S/C25H27N3O5/c1-30-23-11-17(6-7-22(23)33-18-4-3-9-31-15-18)20-12-21-19(5-2-8-26-21)25(28-20)32-14-16-10-24(29)27-13-16/h2,5-8,11-12,16,18H,3-4,9-10,13-15H2,1H3,(H,27,29)/t16-,18+/m1/s1	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.80	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Pharma GmbH & Co. KG US Patent					Assay Description Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...				US Patent US8969568 (2015) BindingDB Entry DOI: 10.7270/Q2154FRD
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