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BDBM14453 1-({1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-(naphthalen-1-yl)-1H-indole-4-carbonitrile::indole analog 4d

SMILES: N#Cc1ccc(Cn2cncc2Cn2ccc3c(C#N)c(ccc23)-c2cccc3ccccc23)cc1

InChI Key: InChIKey=GGWAFGGYEHLURM-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14453   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Geranylgeranyl Transferase (GGTase-I)


(Bos taurus (bovine))
BDBM14453
PNG
(1-({1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl}met...)
Show SMILES N#Cc1ccc(Cn2cncc2Cn2ccc3c(C#N)c(ccc23)-c2cccc3ccccc23)cc1
Show InChI InChI=1S/C31H21N5/c32-16-22-8-10-23(11-9-22)19-36-21-34-18-25(36)20-35-15-14-29-30(17-33)28(12-13-31(29)35)27-7-3-5-24-4-1-2-6-26(24)27/h1-15,18,21H,19-20H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 110n/an/an/an/an/an/a



Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting GGTase-1 was determined by measuring the transfer of [3H]-geranylgeranylpyrophosphate to substrate Ha-R...


Bioorg Med Chem Lett 15: 2033-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.062
BindingDB Entry DOI: 10.7270/Q23J3B61
More data for this
Ligand-Target Pair
Protein Farnesyltransferase (PFT)


(Bos taurus (bovine))
BDBM14453
PNG
(1-({1-[(4-cyanophenyl)methyl]-1H-imidazol-5-yl}met...)
Show SMILES N#Cc1ccc(Cn2cncc2Cn2ccc3c(C#N)c(ccc23)-c2cccc3ccccc23)cc1
Show InChI InChI=1S/C31H21N5/c32-16-22-8-10-23(11-9-22)19-36-21-34-18-25(36)20-35-15-14-29-30(17-33)28(12-13-31(29)35)27-7-3-5-24-4-1-2-6-26(24)27/h1-15,18,21H,19-20H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.150n/an/an/an/a7.537



Abbott Laboratories



Assay Description
The in vitro activity of compounds inhibiting FTase was determined by measuring the transfer of [3H]-FPP to substrate Ha-Ras-CVLS. The incorporated r...


Bioorg Med Chem Lett 15: 2033-9 (2005)


Article DOI: 10.1016/j.bmcl.2005.02.062
BindingDB Entry DOI: 10.7270/Q23J3B61
More data for this
Ligand-Target Pair