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SMILES: COc1cc(ccc1OCC1CCOCC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1

InChI Key: InChIKey=PCWQSWRGRFNKTD-GOSISDBHSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 144549   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase SYK


(Homo sapiens (Human))		BDBM144549
PNG
(US8969568, 102)
Show SMILES COc1cc(ccc1OCC1CCOCC1)-c1cc2ncccc2c(OC[C@H]2CNC(=O)C2)n1 |r|
Show InChI InChI=1S/C26H29N3O5/c1-31-24-12-19(4-5-23(24)33-15-17-6-9-32-10-7-17)21-13-22-20(3-2-8-27-22)26(29-21)34-16-18-11-25(30)28-14-18/h2-5,8,12-13,17-18H,6-7,9-11,14-16H2,1H3,(H,28,30)/t18-/m1/s1
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Similars
US Patent
n/an/a 0.900n/an/an/an/an/an/a



Boehringer Ingelheim Pharma GmbH & Co. KG

US Patent


Assay Description
Recombinant human Syk (amino acids 342-635) was expressed as a fusion protein with an N-terminal GST tag, affinity-purified and deep-frozen at a conc...

US Patent US8969568 (2015)


BindingDB Entry DOI: 10.7270/Q2154FRD
More data for this
Ligand-Target Pair