BindingDB PrimarySearch

BDBM14459 (+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-1-piperidin-yl]-2-oxo-ethyl]-1-piperidinecarboxamide::4-(2-{4-[(2R)-6,15-dibromo-13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl]piperidin-1-yl}-2-oxoethyl)piperidine-1-carboxamide::CHEMBL298734::Lonafarnib::SCH 66336::Sarasar

SMILES: NC(=O)N1CCC(CC(=O)N2CCC(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)CC1

InChI Key: InChIKey=DHMTURDWPRKSOA-RUZDIDTESA-N

Data: 18 IC50 1 EC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 14459
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Plasmodium falciparum (malaria parasite P. falcipa...)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	KEGG UniProtKB/TrEMBL GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>250	n/a	n/a	n/a	n/a	n/a	n/a
University of Washington at Seattle					Assay Description Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...				J Med Chem 48: 3704-13 (2005) Article DOI: 10.1021/jm0491039 BindingDB Entry DOI: 10.7270/Q2BC3WSQ
University of Washington at Seattle					More data for this Ligand-Target Pair
Geranylgeranyl transferase type I beta subunit/Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of human GGTase1 in human Burkitt lymphoma (Daudi) cell supernatant using [3H]geranylgeranyl				Medchemcomm 4: 476-492 (2013) Article DOI: 10.1039/c2md20299a BindingDB Entry DOI: 10.7270/Q2HD7ZN5
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibitory activity against Hras Farnesyltransferase (FPT).				J Med Chem 42: 2651-61 (1999) Article DOI: 10.1021/jm990059k BindingDB Entry DOI: 10.7270/Q2ST7P2V
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Farnesyl protein transferase				J Med Chem 42: 2125-35 (1999) Article DOI: 10.1021/jm990030g BindingDB Entry DOI: 10.7270/Q2ZS2VP9
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB PubMed	n/a	n/a	1.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description In vitro inhibition of human Farnesyltransferase				Bioorg Med Chem Lett 9: 1875-80 (1999) BindingDB Entry DOI: 10.7270/Q29W0DQR
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of Protein farnesyltransferase in Cos-1 monkey kidney cells expressing H-Ras-val				J Med Chem 45: 3854-64 (2002) BindingDB Entry DOI: 10.7270/Q2TD9WPB
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	8.30	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Bovine farnesyltransferase (FTase)				Bioorg Med Chem Lett 14: 5367-70 (2004) Article DOI: 10.1016/j.bmcl.2004.08.012 BindingDB Entry DOI: 10.7270/Q2NS0TC9
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Geranylgeranyl Transferase (GGTase-I) (Bos taurus (bovine))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Bovine geranylgeranyltransferase (GGT)				Bioorg Med Chem Lett 14: 5367-70 (2004) Article DOI: 10.1016/j.bmcl.2004.08.012 BindingDB Entry DOI: 10.7270/Q2NS0TC9
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	5.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of K-Ras transformed NIH3T3 cell proliferation				Bioorg Med Chem Lett 14: 5899-902 (2004) Article DOI: 10.1016/j.bmcl.2004.09.020 BindingDB Entry DOI: 10.7270/Q2PG1R78
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Inhibition of [3H]-FPP incorporation into H-ras CVLS by Farnesyltransferase				Bioorg Med Chem Lett 14: 5899-902 (2004) Article DOI: 10.1016/j.bmcl.2004.09.020 BindingDB Entry DOI: 10.7270/Q2PG1R78
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description Effect on Ras processing in Cos-1 monkey kidney cells expressing either H-Ras-Val 12-CVLS or H-Ras-Val12.				J Med Chem 42: 2651-61 (1999) Article DOI: 10.1021/jm990059k BindingDB Entry DOI: 10.7270/Q2ST7P2V
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit (Mus musculus)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	100	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of Ras farnesylation in H-Ras transformed NIH3T3 cells				Bioorg Med Chem Lett 14: 5367-70 (2004) Article DOI: 10.1016/j.bmcl.2004.08.012 BindingDB Entry DOI: 10.7270/Q2NS0TC9
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Farnesyltransferase (PFT) Chain B (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against farnesyltransferase was determined				J Med Chem 47: 1869-78 (2004) Article DOI: 10.1021/jm0305467 BindingDB Entry DOI: 10.7270/Q2RX9CVX
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
P-glycoprotein 1 (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Schering-Plough Research Institute Curated by ChEMBL					Assay Description TP_TRANSPORTER: inhibition of DNR efflux (DNR: ? uM) in MDR1-expressing NIH3T3 cells				Cancer Res 61: 7525-9 (2001) BindingDB Entry DOI: 10.7270/Q24F1S1P
Schering-Plough Research Institute Curated by ChEMBL					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Bos taurus (bovine))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB PubMed	n/a	n/a	7.80	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description In vitro inhibitory activity of the compound against farnesyltransferase (FTase)				Bioorg Med Chem Lett 13: 1367-71 (2003) BindingDB Entry DOI: 10.7270/Q20K27ZP
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Farnesyltransferase (PFT)/farnesyltransferase beta subunit (Rattus norvegicus-Rattus norvegicus (rat))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Inhibition of rat brain FTase assessed as decrease in transfer of [3H]farnesyl from [3H]farnesyl PPi to H-Ras-CVLS after 30 mins by liquid scintillat...				J Med Chem 61: 3239-3252 (2018) Article DOI: 10.1021/acs.jmedchem.6b01817 BindingDB Entry DOI: 10.7270/Q2542R5N
Temple University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
geranylgeranyltransferase type-I (Rattus norvegicus)	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	>1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Temple University Curated by ChEMBL					Assay Description Inhibition of rat brain GGTase1 assessed as decrease in transfer of [3H]H]geranylgeranyl from [3H]geranylgeranyl PPi to H-Ras-CVLL after 30 mins by l...				J Med Chem 61: 3239-3252 (2018) Article DOI: 10.1021/acs.jmedchem.6b01817 BindingDB Entry DOI: 10.7270/Q2542R5N
Temple University Curated by ChEMBL					More data for this Ligand-Target Pair
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of human recombinant FTase using [3H]farnesyldiphosphate				Medchemcomm 4: 476-492 (2013) Article DOI: 10.1039/c2md20299a BindingDB Entry DOI: 10.7270/Q2HD7ZN5
University of Minnesota Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM14459 ((+)-4-[2-[4-(8-Chloro-3,10-dibromo-6,11-dihydro-5H...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE MMDB PC cid PC sid PDB UniChem Patents Similars	MMDB PDB Article PubMed	n/a	n/a	1.90	n/a	n/a	n/a	n/a	7.5	22
Schering-Plough Research Institute					Assay Description FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...				J Med Chem 41: 4890-902 (1998) Article DOI: 10.1021/jm980462b BindingDB Entry DOI: 10.7270/Q2ZS2TRS
Schering-Plough Research Institute					More data for this Ligand-Target Pair				3D Structure (crystal)