BDBM14461 (+)-4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo-[5,6]cyclohepta[1,2-b]pyridin-11(R)-yl)-4-(4-pyridinyl-acetyl)piperazine N4-Oxide::4-(2-{4-[(2R)-6,15-dibromo-13-chloro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl]piperazin-1-yl}-2-oxoethyl)-1-oxidopyridin-1-ium::Trihalobenzocycloheptapyridine Tricyclic Compound 33

SMILES: [O-][n+]1ccc(CC(=O)N2CCN(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)cc1

InChI Key: InChIKey=RKNQPYFCXGJISA-RUZDIDTESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14461   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Protein Farnesyltransferase (PFT) (Homo sapiens (Human))	BDBM14461 ((+)-4-(3,10-Dibromo-8-chloro-6,11-dihydro-5H-benzo...) Show SMILES [O-][n+]1ccc(CC(=O)N2CCN(CC2)[C@H]2c3ncc(Br)cc3CCc3cc(Cl)cc(Br)c23)cc1 |r| Show InChI InChI=1S/C25H23Br2ClN4O2/c26-19-12-18-2-1-17-13-20(28)14-21(27)23(17)25(24(18)29-15-19)31-9-7-30(8-10-31)22(33)11-16-3-5-32(34)6-4-16/h3-6,12-15,25H,1-2,7-11H2/t25-/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.80	n/a	n/a	n/a	n/a	7.5	22
Schering-Plough Research Institute					Assay Description FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...				J Med Chem 41: 4890-902 (1998) Article DOI: 10.1021/jm980462b BindingDB Entry DOI: 10.7270/Q2ZS2TRS
					More data for this Ligand-Target Pair