BDBM145243 US8952169, 22::US9771376, Example 22

SMILES: CS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3CCCCc3c2)cc1F

InChI Key: InChIKey=RDSLZAYDXWNXJP-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145243   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145243 (US8952169, 22 | US9771376, Example 22) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3CCCCc3c2)cc1F Show InChI InChI=1S/C18H17ClFNO4S/c1-26(23,24)21-18(22)14-9-15(19)17(10-16(14)20)25-13-7-6-11-4-2-3-5-12(11)8-13/h6-10H,2-5H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	190	n/a	n/a	n/a	n/a	7.4	25
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145243 (US8952169, 22 | US9771376, Example 22) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3CCCCc3c2)cc1F Show InChI InChI=1S/C18H17ClFNO4S/c1-26(23,24)21-18(22)14-9-15(19)17(10-16(14)20)25-13-7-6-11-4-2-3-5-12(11)8-13/h6-10H,2-5H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.4	n/a	n/a	n/a	n/a	n/a	n/a
GENENTECH, INC.; XENON PHARMACEUTICALS INC. US Patent					Assay Description The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...				US Patent US9771376 (2017) BindingDB Entry DOI: 10.7270/Q2W0983R
					More data for this Ligand-Target Pair
Sodium channel protein type 9 subunit alpha (Homo sapiens (Human))	BDBM145243 (US8952169, 22 | US9771376, Example 22) Show SMILES CS(=O)(=O)NC(=O)c1cc(Cl)c(Oc2ccc3CCCCc3c2)cc1F Show InChI InChI=1S/C18H17ClFNO4S/c1-26(23,24)21-18(22)14-9-15(19)17(10-16(14)20)25-13-7-6-11-4-2-3-5-12(11)8-13/h6-10H,2-5H2,1H3,(H,21,22)	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	13.4	n/a	n/a	n/a	n/a	n/a	37
Xenon Pharmaceuticals Inc.; Genentech, Inc. US Patent					Assay Description Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...				US Patent US8952169 (2015) BindingDB Entry DOI: 10.7270/Q2M04445
					More data for this Ligand-Target Pair