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BDBM145255 US8952169, 34::US9771376, Example 34

SMILES: CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@H]3C[C@@H]2C3(C)C)cc1F

InChI Key: InChIKey=VGLSLQMDHQYBDV-AVGVCHNINA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145255   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145255
PNG
(US8952169, 34 | US9771376, Example 34)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@H]3C[C@@H]2C3(C)C)cc1F |r|
Show InChI InChI=1/C19H26ClFN2O4S/c1-19(2)12-6-5-11(14(19)7-12)10-27-17-9-16(21)13(8-15(17)20)18(24)22-28(25,26)23(3)4/h8-9,11-12,14H,5-7,10H2,1-4H3,(H,22,24)/t11-,12+,14+/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 38n/an/an/an/a7.425



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) was tritiated. Three tritiums were incorporated in plac...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145255
PNG
(US8952169, 34 | US9771376, Example 34)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@H]3C[C@@H]2C3(C)C)cc1F |r|
Show InChI InChI=1/C19H26ClFN2O4S/c1-19(2)12-6-5-11(14(19)7-12)10-27-17-9-16(21)13(8-15(17)20)18(24)22-28(25,26)23(3)4/h8-9,11-12,14H,5-7,10H2,1-4H3,(H,22,24)/t11-,12+,14+/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 65.8n/an/an/an/an/an/a



GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent




US Patent US9771376 (2017)


BindingDB Entry DOI: 10.7270/Q2W0983R
More data for this
Ligand-Target Pair
Sodium channel protein type 9 subunit alpha


(Homo sapiens (Human))
BDBM145255
PNG
(US8952169, 34 | US9771376, Example 34)
Show SMILES CN(C)S(=O)(=O)NC(=O)c1cc(Cl)c(OC[C@H]2CC[C@H]3C[C@@H]2C3(C)C)cc1F |r|
Show InChI InChI=1/C19H26ClFN2O4S/c1-19(2)12-6-5-11(14(19)7-12)10-27-17-9-16(21)13(8-15(17)20)18(24)22-28(25,26)23(3)4/h8-9,11-12,14H,5-7,10H2,1-4H3,(H,22,24)/t11-,12+,14+/s2
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 65.8n/an/an/an/an/a37



Xenon Pharmaceuticals Inc.; Genentech, Inc.

US Patent


Assay Description
Patch voltage clamp electrophysiology allows for the direct measurement and quantification of block of voltage-gated sodium channels (NaV's), and all...


US Patent US8952169 (2015)


BindingDB Entry DOI: 10.7270/Q2M04445
More data for this
Ligand-Target Pair