BDBM14533 2-[6-(3-aminophenyl)-3-(butylamino)-5-chloro-2-oxo-1,2-dihydropyrazin-1-yl]-N-[(4-carbamimidoylphenyl)methyl]acetamide::Pyrazinone Analog 29c

SMILES: CCCCNc1nc(Cl)c(-c2cccc(N)c2)n(CC(=O)NCc2ccc(cc2)C(N)=N)c1=O

InChI Key: InChIKey=OYNIGSOZAGAEKP-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14533   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor VII (Homo sapiens (Human))	BDBM14533 (2-[6-(3-aminophenyl)-3-(butylamino)-5-chloro-2-oxo...) Show SMILES CCCCNc1nc(Cl)c(-c2cccc(N)c2)n(CC(=O)NCc2ccc(cc2)C(N)=N)c1=O Show InChI InChI=1S/C24H28ClN7O2/c1-2-3-11-29-23-24(34)32(20(21(25)31-23)17-5-4-6-18(26)12-17)14-19(33)30-13-15-7-9-16(10-8-15)22(27)28/h4-10,12H,2-3,11,13-14,26H2,1H3,(H3,27,28)(H,29,31)(H,30,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia Corporation					Assay Description Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...				J Med Chem 46: 4050-62 (2003) Article DOI: 10.1021/jm030131l BindingDB Entry DOI: 10.7270/Q2FT8J9M
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM14533 (2-[6-(3-aminophenyl)-3-(butylamino)-5-chloro-2-oxo...) Show SMILES CCCCNc1nc(Cl)c(-c2cccc(N)c2)n(CC(=O)NCc2ccc(cc2)C(N)=N)c1=O Show InChI InChI=1S/C24H28ClN7O2/c1-2-3-11-29-23-24(34)32(20(21(25)31-23)17-5-4-6-18(26)12-17)14-19(33)30-13-15-7-9-16(10-8-15)22(27)28/h4-10,12H,2-3,11,13-14,26H2,1H3,(H3,27,28)(H,29,31)(H,30,33)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1.79E+4	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia Corporation					Assay Description Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...				J Med Chem 46: 4050-62 (2003) Article DOI: 10.1021/jm030131l BindingDB Entry DOI: 10.7270/Q2FT8J9M
					More data for this Ligand-Target Pair