BDBM145681 US8952177, 35::US9089569, 35::US9695149, 35

SMILES: Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)-c4ccc(cc4)C(F)(F)F)c3c2)nc1

InChI Key: InChIKey=HFHYJUFFDJGTLK-ZSXSBBPPSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145681   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145681 (US8952177, 35 | US9089569, 35 | US9695149, 35) Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)-c4ccc(cc4)C(F)(F)F)c3c2)nc1 |r| Show InChI InChI=1S/C35H32F3N3O3/c1-22-6-15-27(39-19-22)21-44-28-16-17-31-32(18-28)41(33(40-31)29-4-2-3-5-30(29)34(42)43)20-23-7-9-24(10-8-23)25-11-13-26(14-12-25)35(36,37)38/h6-19,29-30H,2-5,20-21H2,1H3,(H,42,43)/t29?,30-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145681 (US8952177, 35 | US9089569, 35 | US9695149, 35) Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)-c4ccc(cc4)C(F)(F)F)c3c2)nc1 |r| Show InChI InChI=1S/C35H32F3N3O3/c1-22-6-15-27(39-19-22)21-44-28-16-17-31-32(18-28)41(33(40-31)29-4-2-3-5-30(29)34(42)43)20-23-7-9-24(10-8-23)25-11-13-26(14-12-25)35(36,37)38/h6-19,29-30H,2-5,20-21H2,1H3,(H,42,43)/t29?,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145681 (US8952177, 35 | US9089569, 35 | US9695149, 35) Show SMILES Cc1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)-c4ccc(cc4)C(F)(F)F)c3c2)nc1 |r| Show InChI InChI=1S/C35H32F3N3O3/c1-22-6-15-27(39-19-22)21-44-28-16-17-31-32(18-28)41(33(40-31)29-4-2-3-5-30(29)34(42)43)20-23-7-9-24(10-8-23)25-11-13-26(14-12-25)35(36,37)38/h6-19,29-30H,2-5,20-21H2,1H3,(H,42,43)/t29?,30-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.90	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair