BDBM145682 US8952177, 36::US8952177, 45::US9089569, 36::US9695149, 36

SMILES: Cn1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)n1

InChI Key: InChIKey=VFVJDKGSEZYQQO-KEKNWZKVSA-N

Data: 4 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 145682   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase-activating protein (FLAP) (Homo sapiens (Human))	BDBM145682 (US8952177, 36 | US8952177, 45 | US9089569, 36 | US...) Show SMILES Cn1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)n1 |r| Show InChI InChI=1S/C27H27F3N4O4/c1-33-13-12-18(32-33)16-37-20-10-11-23-24(14-20)34(15-17-6-8-19(9-7-17)38-27(28,29)30)25(31-23)21-4-2-3-5-22(21)26(35)36/h6-14,21-22H,2-5,15-16H2,1H3,(H,35,36)/t21?,22-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM145682 (US8952177, 36 | US8952177, 45 | US9089569, 36 | US...) Show SMILES Cn1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)n1 |r| Show InChI InChI=1S/C27H27F3N4O4/c1-33-13-12-18(32-33)16-37-20-10-11-23-24(14-20)34(15-17-6-8-19(9-7-17)38-27(28,29)30)25(31-23)21-4-2-3-5-22(21)26(35)36/h6-14,21-22H,2-5,15-16H2,1H3,(H,35,36)/t21?,22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM145682 (US8952177, 36 | US8952177, 45 | US9089569, 36 | US...) Show SMILES Cn1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)n1 |r| Show InChI InChI=1S/C27H27F3N4O4/c1-33-13-12-18(32-33)16-37-20-10-11-23-24(14-20)34(15-17-6-8-19(9-7-17)38-27(28,29)30)25(31-23)21-4-2-3-5-22(21)26(35)36/h6-14,21-22H,2-5,15-16H2,1H3,(H,35,36)/t21?,22-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.20	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP) (Homo sapiens (Human))	BDBM145682 (US8952177, 36 | US8952177, 45 | US9089569, 36 | US...) Show SMILES Cn1ccc(COc2ccc3nc(C4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)cc4)c3c2)n1 |r| Show InChI InChI=1S/C27H27F3N4O4/c1-33-13-12-18(32-33)16-37-20-10-11-23-24(14-20)34(15-17-6-8-19(9-7-17)38-27(28,29)30)25(31-23)21-4-2-3-5-22(21)26(35)36/h6-14,21-22H,2-5,15-16H2,1H3,(H,35,36)/t21?,22-/m0/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.50E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair