BDBM145726 US8952177, 80::US9089569, 80::US9695149, 80

SMILES: Cc1ccc(COc2ccc3nc(C4CCCCC4)n(Cc4ccc(cc4)-c4ncc(Cl)cn4)c3c2)nc1

InChI Key: InChIKey=UNWDHUIJLMMKMA-UHFFFAOYSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 145726   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM145726 (US8952177, 80 | US9089569, 80 | US9695149, 80) Show SMILES Cc1ccc(COc2ccc3nc(C4CCCCC4)n(Cc4ccc(cc4)-c4ncc(Cl)cn4)c3c2)nc1 Show InChI InChI=1S/C31H30ClN5O/c1-21-7-12-26(33-16-21)20-38-27-13-14-28-29(15-27)37(31(36-28)24-5-3-2-4-6-24)19-22-8-10-23(11-9-22)30-34-17-25(32)18-35-30/h7-18,24H,2-6,19-20H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP) (Homo sapiens (Human))	BDBM145726 (US8952177, 80 | US9089569, 80 | US9695149, 80) Show SMILES Cc1ccc(COc2ccc3nc(C4CCCCC4)n(Cc4ccc(cc4)-c4ncc(Cl)cn4)c3c2)nc1 Show InChI InChI=1S/C31H30ClN5O/c1-21-7-12-26(33-16-21)20-38-27-13-14-28-29(15-27)37(31(36-28)24-5-3-2-4-6-24)19-22-8-10-23(11-9-22)30-34-17-25(32)18-35-30/h7-18,24H,2-6,19-20H2,1H3	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	3.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair