BDBM145755 US8952177, 109::US9089569, 109::US9695149, 109

SMILES: Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)c(C)c4)c3c2)nc1

InChI Key: InChIKey=DMWYBVXSZUBCQF-RPWUZVMVSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145755   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145755 (US8952177, 109 | US9089569, 109 | US9695149, 109) Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)c(C)c4)c3c2)nc1 |r| Show InChI InChI=1S/C30H30F3N3O4/c1-18-7-9-21(34-15-18)17-39-22-10-11-25-26(14-22)36(28(35-25)23-5-3-4-6-24(23)29(37)38)16-20-8-12-27(19(2)13-20)40-30(31,32)33/h7-15,23-24H,3-6,16-17H2,1-2H3,(H,37,38)/t23-,24+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145755 (US8952177, 109 | US9089569, 109 | US9695149, 109) Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)c(C)c4)c3c2)nc1 |r| Show InChI InChI=1S/C30H30F3N3O4/c1-18-7-9-21(34-15-18)17-39-22-10-11-25-26(14-22)36(28(35-25)23-5-3-4-6-24(23)29(37)38)16-20-8-12-27(19(2)13-20)40-30(31,32)33/h7-15,23-24H,3-6,16-17H2,1-2H3,(H,37,38)/t23-,24+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145755 (US8952177, 109 | US9089569, 109 | US9695149, 109) Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(OC(F)(F)F)c(C)c4)c3c2)nc1 |r| Show InChI InChI=1S/C30H30F3N3O4/c1-18-7-9-21(34-15-18)17-39-22-10-11-25-26(14-22)36(28(35-25)23-5-3-4-6-24(23)29(37)38)16-20-8-12-27(19(2)13-20)40-30(31,32)33/h7-15,23-24H,3-6,16-17H2,1-2H3,(H,37,38)/t23-,24+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	2.60	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair