BDBM145823 US8952177, 179::US9089569, 179::US9695149, 179

SMILES: Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)N4CCCCC4)c3c2)c(F)c1

InChI Key: InChIKey=KOKXSVVBCFYWNG-SXOMAYOGSA-N

Data: 3 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 145823   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145823 (US8952177, 179 | US9089569, 179 | US9695149, 179) Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)N4CCCCC4)c3c2)c(F)c1 |r| Show InChI InChI=1S/C33H37FN4O3/c1-22-17-28(34)30(35-19-22)21-41-25-13-14-29-31(18-25)38(32(36-29)26-7-3-4-8-27(26)33(39)40)20-23-9-11-24(12-10-23)37-15-5-2-6-16-37/h9-14,17-19,26-27H,2-8,15-16,20-21H2,1H3,(H,39,40)/t26-,27+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145823 (US8952177, 179 | US9089569, 179 | US9695149, 179) Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)N4CCCCC4)c3c2)c(F)c1 |r| Show InChI InChI=1S/C33H37FN4O3/c1-22-17-28(34)30(35-19-22)21-41-25-13-14-29-31(18-25)38(32(36-29)26-7-3-4-8-27(26)33(39)40)20-23-9-11-24(12-10-23)37-15-5-2-6-16-37/h9-14,17-19,26-27H,2-8,15-16,20-21H2,1H3,(H,39,40)/t26-,27+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
Arachidonate 5-lipoxygenase-activating protein (Homo sapiens (Human))	BDBM145823 (US8952177, 179 | US9089569, 179 | US9695149, 179) Show SMILES Cc1cnc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(cc4)N4CCCCC4)c3c2)c(F)c1 |r| Show InChI InChI=1S/C33H37FN4O3/c1-22-17-28(34)30(35-19-22)21-41-25-13-14-29-31(18-25)38(32(36-29)26-7-3-4-8-27(26)33(39)40)20-23-9-11-24(12-10-23)37-15-5-2-6-16-37/h9-14,17-19,26-27H,2-8,15-16,20-21H2,1H3,(H,39,40)/t26-,27+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.30	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9089569 (2015) BindingDB Entry DOI: 10.7270/Q23X85DB
					More data for this Ligand-Target Pair