BDBM145835 US8952177, 2::US9695149, 2

SMILES: Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)nc1

InChI Key: InChIKey=RPNGLHUBZFJLRE-RPWUZVMVSA-N

Data: 2 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 145835   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-lipoxygenase/FLAP (Homo sapiens (Human))	BDBM145835 (US8952177, 2 | US9695149, 2) Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)nc1 Show InChI InChI=1S/C28H28BrN3O3/c1-18-6-11-21(30-15-18)17-35-22-12-13-25-26(14-22)32(16-19-7-9-20(29)10-8-19)27(31-25)23-4-2-3-5-24(23)28(33)34/h6-15,23-24H,2-5,16-17H2,1H3,(H,33,34)/t23-,24+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
JANSSEN PHARMACEUTICA NV US Patent					Assay Description The assay below is used to test the modulatory activity of compounds against FLAP. Human and mouse FLAP-encoding DNA was amplified by polymerase chai...				US Patent US9695149 (2017) BindingDB Entry DOI: 10.7270/Q2Q52MSC
					More data for this Ligand-Target Pair
5-lipoxygenase-activating protein (FLAP) (Homo sapiens (Human))	BDBM145835 (US8952177, 2 | US9695149, 2) Show SMILES Cc1ccc(COc2ccc3nc([C@@H]4CCCC[C@@H]4C(O)=O)n(Cc4ccc(Br)cc4)c3c2)nc1 Show InChI InChI=1S/C28H28BrN3O3/c1-18-6-11-21(30-15-18)17-35-22-12-13-25-26(14-22)32(16-19-7-9-20(29)10-8-19)27(31-25)23-4-2-3-5-24(23)28(33)34/h6-15,23-24H,2-5,16-17H2,1H3,(H,33,34)/t23-,24+/m1/s1	PDB KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	1.40	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Janssen Pharmaceutica NV US Patent					Assay Description FLAP-containing membranes were prepared as was a FITC-labeled FLAP modulator (3-(3-(tert-butylthio)-1-(4-chlorobenzyl)-5-(quinolin-2-ylmethoxy)-1H-in...				US Patent US8952177 (2015) BindingDB Entry DOI: 10.7270/Q2G73CFW
					More data for this Ligand-Target Pair