BDBM14592 N-[(4-carbamimidoylphenyl)methyl]-2-[5-chloro-6-(3-methanesulfonamidophenyl)-2-oxo-3-[(2-phenylethyl)amino]-1,2-dihydropyrazin-1-yl]acetamide::Pyrazinone Analog 33e

SMILES: CS(=O)(=O)Nc1cccc(c1)-c1c(Cl)nc(NCCc2ccccc2)c(=O)n1CC(=O)NCc1ccc(cc1)C(N)=N

InChI Key: InChIKey=AXZMLQRFBDPEMG-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 14592   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Coagulation factor VII (Homo sapiens (Human))	BDBM14592 (N-[(4-carbamimidoylphenyl)methyl]-2-[5-chloro-6-(3...) Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1c(Cl)nc(NCCc2ccccc2)c(=O)n1CC(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C29H30ClN7O4S/c1-42(40,41)36-23-9-5-8-22(16-23)25-26(30)35-28(33-15-14-19-6-3-2-4-7-19)29(39)37(25)18-24(38)34-17-20-10-12-21(13-11-20)27(31)32/h2-13,16,36H,14-15,17-18H2,1H3,(H3,31,32)(H,33,35)(H,34,38)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia Corporation					Assay Description Recombinant human Factor VIIa and soluble tissue factor were added to a 96-well assay plate containing substrate and inhibitor in reaction buffer. Th...				J Med Chem 46: 4050-62 (2003) Article DOI: 10.1021/jm030131l BindingDB Entry DOI: 10.7270/Q2FT8J9M
					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM14592 (N-[(4-carbamimidoylphenyl)methyl]-2-[5-chloro-6-(3...) Show SMILES CS(=O)(=O)Nc1cccc(c1)-c1c(Cl)nc(NCCc2ccccc2)c(=O)n1CC(=O)NCc1ccc(cc1)C(N)=N Show InChI InChI=1S/C29H30ClN7O4S/c1-42(40,41)36-23-9-5-8-22(16-23)25-26(30)35-28(33-15-14-19-6-3-2-4-7-19)29(39)37(25)18-24(38)34-17-20-10-12-21(13-11-20)27(31)32/h2-13,16,36H,14-15,17-18H2,1H3,(H3,31,32)(H,33,35)(H,34,38)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
Pharmacia Corporation					Assay Description Human thrombin and substrate were added to a 96-well assay plate containing inhibitor in reaction buffer. The rate of hydrolysis of the substrate was...				J Med Chem 46: 4050-62 (2003) Article DOI: 10.1021/jm030131l BindingDB Entry DOI: 10.7270/Q2FT8J9M
					More data for this Ligand-Target Pair