BDBM147027 US8957074, 67

SMILES: CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)C(=O)N3CC4CC3CN4)nc2n1C1CCCCC1

InChI Key: InChIKey=GYESOKVQMVWQTH-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 147027   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 1 (Homo sapiens (Human))	BDBM147027 (US8957074, 67) Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)C(=O)N3CC4CC3CN4)nc2n1C1CCCCC1 Show InChI InChI=1S/C26H32N8O2/c1-32(2)25(36)21-10-17-13-29-26(31-23(17)34(21)19-6-4-3-5-7-19)30-22-9-8-16(12-28-22)24(35)33-15-18-11-20(33)14-27-18/h8-10,12-13,18-20,27H,3-7,11,14-15H2,1-2H3,(H,28,29,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.04E+4	n/a	n/a	n/a	n/a	n/a	25
Novartis AG US Patent					Assay Description A 384-well microtiter IMAP-FP (Molecular Devices Trade Mark Technology) endpoint assay was used for CDK1/cyclin B kinase activity measurements. The s...				US Patent US8957074 (2015) BindingDB Entry DOI: 10.7270/Q2K0730S
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4 (Homo sapiens (Human))	BDBM147027 (US8957074, 67) Show SMILES CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)C(=O)N3CC4CC3CN4)nc2n1C1CCCCC1 Show InChI InChI=1S/C26H32N8O2/c1-32(2)25(36)21-10-17-13-29-26(31-23(17)34(21)19-6-4-3-5-7-19)30-22-9-8-16(12-28-22)24(35)33-15-18-11-20(33)14-27-18/h8-10,12-13,18-20,27H,3-7,11,14-15H2,1-2H3,(H,28,29,30,31)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	7.5	22
Novartis AG US Patent					Assay Description An assay for monitoring CDK4/cyclin D1-catalyzed phosphorylation of pRb at the Ser780 site was performed using TR-FRET in a 384-well format, and was ...				US Patent US8957074 (2015) BindingDB Entry DOI: 10.7270/Q2K0730S
					More data for this Ligand-Target Pair