BDBM14772 (R,S)-Mesopram::5-(4-methoxy-3-propoxy-phenyl)-5-methyl-1,3-oxazolidin-2-one::5-(4-methoxy-3-propoxyphenyl)-5-methyl-1,3-oxazolidin-2-one::Daxalipram
SMILES: CCCOc1cc(ccc1OC)C1(C)CNC(=O)O1
InChI Key: InChIKey=PCCPERGCFKIYIS-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B (Homo sapiens (Human)) | BDBM14772 ((R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 2 (PDE2A) (Homo sapiens (Human)) | BDBM14772 ((R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | 7.5 | 30 |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-inhibited 3',5'-cyclic phosphodiesterase B (aa 650-1084) (Homo sapiens (Human)) | BDBM14772 ((R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 4 (PDE4B) (Homo sapiens (Human)) | BDBM14772 ((R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-...) | PDB MMDB B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1 | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Phosphodiesterase Type 4 (PDE4D) (Homo sapiens (Human)) | BDBM14772 ((R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-...) | PDB MMDB B.MOAD GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 11 (PDE11A) (Homo sapiens (Human)) | BDBM14772 ((R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-...) | GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 7 (PDE7B) (Homo sapiens (Human)) | BDBM14772 ((R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-...) | Reactome pathway KEGG DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase 8 (Homo sapiens (Human)) | BDBM14772 ((R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 9 (PDE9A) (Homo sapiens (Human)) | BDBM14772 ((R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-...) | PDB MMDB NCI pathway Reactome pathway KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 10 (PDE10A) (Homo sapiens (Human)) | BDBM14772 ((R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Phosphodiesterase Type 5 (PDE5A) (Homo sapiens (Human)) | BDBM14772 ((R,S)-Mesopram | 5-(4-methoxy-3-propoxy-phenyl)-5-...) | PDB MMDB KEGG B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Plexxikon | Assay Description Phosphodiesterase activities were assayed in the presence of inhibitor compounds. Measurement takes advantage of the selective binding of 5-AMP or 5-... | Structure 12: 2233-47 (2004) Article DOI: 10.1016/j.str.2004.10.004 BindingDB Entry DOI: 10.7270/Q25B00Q1 | |||||||||||
More data for this Ligand-Target Pair |