null
SMILES: NCc1ccc(cc1-c1cccc(NC(=O)c2ccc(SC3CCOC3=O)cc2)c1)C(=O)Nc1ccncc1F
InChI Key: InChIKey=QKLHHIYLYLZRFM-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rho-associated protein kinase 2 (Homo sapiens (Human)) | BDBM148410 (US9682963, 4) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | <100 | n/a | n/a | n/a | n/a | 7.5 | 25 |
Redx Pharma PLC US Patent | Assay Description Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO. Required cofactor... | US Patent US9682963 (2017) BindingDB Entry DOI: 10.7270/Q2FJ2DZF | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1/2 (Rattus norvegicus (Rat)) | BDBM148410 (US9682963, 4) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <100 | n/a | n/a | n/a | n/a |
Redx Pharma PLC US Patent | Assay Description Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ... | US Patent US9682963 (2017) BindingDB Entry DOI: 10.7270/Q2FJ2DZF | |||||||||||
More data for this Ligand-Target Pair |