null

SMILES: NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1cccc(SC2CCOC2=O)c1)C(=O)Nc1ccncc1F

InChI Key: InChIKey=WGVDEBYCDHJUAL-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148415   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM148415 (US9682963, 8) Show SMILES NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1cccc(SC2CCOC2=O)c1)C(=O)Nc1ccncc1F Show InChI InChI=1S/C30H25FN4O4S/c31-25-17-33-11-9-26(25)35-29(37)20-7-8-21(16-32)24(14-20)18-3-1-4-19(13-18)28(36)34-22-5-2-6-23(15-22)40-27-10-12-39-30(27)38/h1-9,11,13-15,17,27H,10,12,16,32H2,(H,34,36)(H,33,35,37)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.5	25
Redx Pharma PLC US Patent					Assay Description Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO. Required cofactor...				US Patent US9682963 (2017) BindingDB Entry DOI: 10.7270/Q2FJ2DZF
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1/2 (Rattus norvegicus (Rat))	BDBM148415 (US9682963, 8) Show SMILES NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1cccc(SC2CCOC2=O)c1)C(=O)Nc1ccncc1F Show InChI InChI=1S/C30H25FN4O4S/c31-25-17-33-11-9-26(25)35-29(37)20-7-8-21(16-32)24(14-20)18-3-1-4-19(13-18)28(36)34-22-5-2-6-23(15-22)40-27-10-12-39-30(27)38/h1-9,11,13-15,17,27H,10,12,16,32H2,(H,34,36)(H,33,35,37)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	550	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent					Assay Description Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...				US Patent US9682963 (2017) BindingDB Entry DOI: 10.7270/Q2FJ2DZF
					More data for this Ligand-Target Pair