null

SMILES: NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1ccc(SC2CCOC2=O)cc1F)C(=O)Nc1ccncc1F

InChI Key: InChIKey=FDMWAVWLRCSEHJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 148423   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 2 (Homo sapiens (Human))	BDBM148423 (US9682963, 12) Show SMILES NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1ccc(SC2CCOC2=O)cc1F)C(=O)Nc1ccncc1F Show InChI InChI=1S/C30H24F2N4O4S/c31-23-14-21(41-27-9-11-40-30(27)39)6-7-25(23)35-28(37)18-3-1-2-17(12-18)22-13-19(4-5-20(22)15-33)29(38)36-26-8-10-34-16-24(26)32/h1-8,10,12-14,16,27H,9,11,15,33H2,(H,35,37)(H,34,36,38)	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	<100	n/a	n/a	n/a	n/a	7.5	25
Redx Pharma PLC US Patent					Assay Description Base Reaction buffer; 20 mM Hepes (pH 7.5), 10 mM MgCl2, 1 mM EGTA, 0.02% Brij35, 0.02 mg/ml BSA, 0.1 mM Na3VO4, 2 mM DTT, 1% DMSO. Required cofactor...				US Patent US9682963 (2017) BindingDB Entry DOI: 10.7270/Q2FJ2DZF
					More data for this Ligand-Target Pair
Rho-associated protein kinase 1/2 (Rattus norvegicus (Rat))	BDBM148423 (US9682963, 12) Show SMILES NCc1ccc(cc1-c1cccc(c1)C(=O)Nc1ccc(SC2CCOC2=O)cc1F)C(=O)Nc1ccncc1F Show InChI InChI=1S/C30H24F2N4O4S/c31-23-14-21(41-27-9-11-40-30(27)39)6-7-25(23)35-28(37)18-3-1-2-17(12-18)22-13-19(4-5-20(22)15-33)29(38)36-26-8-10-34-16-24(26)32/h1-8,10,12-14,16,27H,9,11,15,33H2,(H,35,37)(H,34,36,38)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	<100	n/a	n/a	n/a	n/a
Redx Pharma PLC US Patent					Assay Description Rat smooth muscle cell line A7r5 is used. The endogenous expression of ROCK results in a constitutive phosphorylation of the regulatory myosin light ...				US Patent US9682963 (2017) BindingDB Entry DOI: 10.7270/Q2FJ2DZF
					More data for this Ligand-Target Pair