BindingDB PrimarySearch

BDBM14864 5-azaindole analog 2::{[3-(2-hydroxy-3-{1H-pyrrolo[3,2-c]pyridin-2-yl}phenyl)phenyl]methyl}urea

SMILES: NC(=O)NCc1cccc(c1)-c1cccc(-c2cc3cnccc3[nH]2)c1O

InChI Key: InChIKey=SRPOHNDQBDHONJ-UHFFFAOYSA-N

Data: 4 KI

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 14864
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Coagulation factor VII (Homo sapiens (Human))	BDBM14864 (5-azaindole analog 2 \| {[3-(2-hydroxy-3-{1H-pyrrol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	800	-8.23	n/a	n/a	n/a	n/a	n/a	7.4	22
Celera					Assay Description The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...				Bioorg Med Chem Lett 16: 3197-200 (2006) Article DOI: 10.1016/j.bmcl.2006.03.049 BindingDB Entry DOI: 10.7270/Q20P0X9Q
Celera					More data for this Ligand-Target Pair				3D Structure (crystal)
Trypsin (Bos taurus (bovine))	BDBM14864 (5-azaindole analog 2 \| {[3-(2-hydroxy-3-{1H-pyrrol...) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	4.65E+4	-5.85	n/a	n/a	n/a	n/a	n/a	7.4	22
Celera					Assay Description The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...				Bioorg Med Chem Lett 16: 3197-200 (2006) Article DOI: 10.1016/j.bmcl.2006.03.049 BindingDB Entry DOI: 10.7270/Q20P0X9Q
Celera					More data for this Ligand-Target Pair
Prothrombin (Homo sapiens (Human))	BDBM14864 (5-azaindole analog 2 \| {[3-(2-hydroxy-3-{1H-pyrrol...) Show SMILES Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	7.15E+4	-5.59	n/a	n/a	n/a	n/a	n/a	7.4	22
Celera					Assay Description The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...				Bioorg Med Chem Lett 16: 3197-200 (2006) Article DOI: 10.1016/j.bmcl.2006.03.049 BindingDB Entry DOI: 10.7270/Q20P0X9Q
Celera					More data for this Ligand-Target Pair
Coagulation factor X (Homo sapiens (Human))	BDBM14864 (5-azaindole analog 2 \| {[3-(2-hydroxy-3-{1H-pyrrol...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	DrugBank MMDB PC cid PC sid PDB UniChem Similars	Article PubMed	1.25E+5	-5.27	n/a	n/a	n/a	n/a	n/a	7.4	22
Celera					Assay Description The enzyme reactions were initiated by the addition of substrate, and the color developed from the release of p-nitroanilide from each chromogenic su...				Bioorg Med Chem Lett 16: 3197-200 (2006) Article DOI: 10.1016/j.bmcl.2006.03.049 BindingDB Entry DOI: 10.7270/Q20P0X9Q
Celera					More data for this Ligand-Target Pair