BDBM149479 US8975261, TT1

SMILES: COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1\C=C\c1cccnc1

InChI Key: InChIKey=OFFGURFOHFNSOB-OANMOWAGSA-N

Data: 1 KI

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 149479   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human))	BDBM149479 (US8975261, TT1) Show SMILES COc1ccc(nc1)[C@H]1C[C@@H]1COc1nc(C)ncc1\C=C\c1cccnc1 |r| Show InChI InChI=1S/C22H22N4O2/c1-15-24-12-17(6-5-16-4-3-9-23-11-16)22(26-15)28-14-18-10-20(18)21-8-7-19(27-2)13-25-21/h3-9,11-13,18,20H,10,14H2,1-2H3/b6-5+/t18-,20+/m1/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description In a typical experiment the PDE10 inhibitory activity of the compounds of the present invention was determined in accordance with the following exper...				US Patent US8975261 (2015) BindingDB Entry DOI: 10.7270/Q2JS9P5F
					More data for this Ligand-Target Pair