null
SMILES: CCOC(=O)c1c(CC)c([nH]c1C=O)C(=O)OC(C)(C)C
InChI Key: InChIKey=BNPQXRAHFOXOEJ-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Insulin-like growth factor 1 receptor (Homo sapiens (Human)) | BDBM15015 (2-tert-Butyl 4-Ethyl 3-Ethyl-5-formyl-1H-pyrrole-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 490 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories | Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore... | Biochemistry 44: 9430-40 (2005) Article DOI: 10.1021/bi0500628 BindingDB Entry DOI: 10.7270/Q2BV7DV5 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin-like growth factor 1 receptor (Homo sapiens (Human)) | BDBM15015 (2-tert-Butyl 4-Ethyl 3-Ethyl-5-formyl-1H-pyrrole-2...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 490 | n/a | n/a | n/a | n/a | n/a | n/a |
Covalution Pharma BV Curated by ChEMBL | Assay Description Inhibition of IGF-1R | J Med Chem 55: 6243-62 (2012) Article DOI: 10.1021/jm3003203 BindingDB Entry DOI: 10.7270/Q2X92CGP | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Insulin receptor (Homo sapiens (Human)) | BDBM15015 (2-tert-Butyl 4-Ethyl 3-Ethyl-5-formyl-1H-pyrrole-2...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | 7.4 | 22 |
Merck Research Laboratories | Assay Description The assay uses purified enzyme interacting with biotinylated peptide substrate.HTRF is based on the proximity of europium cryptate (donor fluorophore... | Biochemistry 44: 9430-40 (2005) Article DOI: 10.1021/bi0500628 BindingDB Entry DOI: 10.7270/Q2BV7DV5 | |||||||||||
More data for this Ligand-Target Pair |