BDBM15067 (2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridin-3-yl)oxy-propan-2-amine::13a (S-)::5-isoquinolinyl pyridine 2::6-{5-[(2S)-2-amino-3-(1H-indol-3-yl)propoxy]pyridin-3-yl}isoquinoline::isoquinoline-pyridine, 1::isoquinoline-pyridine, 3::pyridine-base inhibitor 13a
SMILES: N[C@H](COc1cncc(c1)-c1ccc2cnccc2c1)Cc1c[nH]c2ccccc12
InChI Key: InChIKey=LHQWPYOYDRVMFI-QFIPXVFZSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Protein kinase B (Akt 1) (Homo sapiens (Human)) | BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) | PDB MMDB B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 2 | -11.7 | n/a | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat... | Bioorg Med Chem Lett 16: 3740-4 (2006) Article DOI: 10.1016/j.bmcl.2006.04.046 BindingDB Entry DOI: 10.7270/Q2ZP44C9 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase Chk1 (Homo sapiens (Human)) | BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | 5.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories Curated by ChEMBL | Assay Description Inhibition of Chk1 | J Med Chem 52: 3159-65 (2009) Article DOI: 10.1021/jm801444x BindingDB Entry DOI: 10.7270/Q2FF3TM8 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase B (Akt 1) (Homo sapiens (Human)) | BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) | PDB MMDB B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories | Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat... | Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase AKT2 (Homo sapiens (Human)) | BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 6.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories | Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat... | Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Serine/threonine-protein kinase AKT (Homo sapiens (Human)) | BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 35 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories | Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat... | Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
RAC-alpha serine/threonine-protein kinase (Homo sapiens (Human)) | BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) | PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Zhejiang University Curated by ChEMBL | Assay Description Inhibition of Akt | Eur J Med Chem 44: 4090-7 (2009) Article DOI: 10.1016/j.ejmech.2009.04.050 BindingDB Entry DOI: 10.7270/Q2GT5N74 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C, gamma (Homo sapiens (Human)) | BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories | Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi... | Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase C (PKC) (Homo sapiens (Human)) | BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 6.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories | Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi... | Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase B (Akt 1) (Homo sapiens (Human)) | BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) | PDB MMDB B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat... | J Med Chem 50: 2990-3003 (2007) Article DOI: 10.1021/jm0701019 BindingDB Entry DOI: 10.7270/Q24X562F | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase B (Akt 1) (Homo sapiens (Human)) | BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) | PDB MMDB B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat... | Bioorg Med Chem Lett 16: 3150-5 (2006) Article DOI: 10.1016/j.bmcl.2006.03.041 BindingDB Entry DOI: 10.7270/Q2F769TT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein kinase B (Akt 1) (Homo sapiens (Human)) | BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) | PDB MMDB B.MOAD GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.5 | 22 |
Abbott Laboratories | Assay Description The kinase assay uses His-Akt1 and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidin-coated FLASH plat... | Bioorg Med Chem Lett 16: 3424-9 (2006) Article DOI: 10.1016/j.bmcl.2006.04.005 BindingDB Entry DOI: 10.7270/Q2K072JJ | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-Dependent Protein Kinase (PKA) (Bos taurus (bovine)) | BDBM15067 ((2S)-1-(1H-indol-3-yl)-3-(5-isoquinolin-6-ylpyridi...) | PDB UniProtKB/SwissProt GoogleScholar AffyNet | MMDB PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 2.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories | Assay Description The kinase assay uses purified recombinant enzyme and a biotinylated peptide as substrate. The biotinylated peptides were immobilized on streptavidi... | Bioorg Med Chem Lett 16: 2000-7 (2006) Article DOI: 10.1016/j.bmcl.2005.12.065 BindingDB Entry DOI: 10.7270/Q2765CKX | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) |