BDBM150811 US8981106, 1 (SX-517)::USRE47267, Compound 1
SMILES: OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
InChI Key: InChIKey=VZRIHFZJVIOJBE-UHFFFAOYSA-N
Data: 14 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | 37 |
Syntrix Biosystems, Inc. US Patent | Assay Description An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+... | US Patent US8981106 (2015) BindingDB Entry DOI: 10.7270/Q2WW7GC1 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems Curated by ChEMBL | Assay Description Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa... | J Med Chem 57: 8378-97 (2014) Article DOI: 10.1021/jm500827t BindingDB Entry DOI: 10.7270/Q2FX7C22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 210 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems Curated by ChEMBL | Assay Description Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based... | J Med Chem 57: 8378-97 (2014) Article DOI: 10.1021/jm500827t BindingDB Entry DOI: 10.7270/Q2FX7C22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 880 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems Curated by ChEMBL | Assay Description Antagonist activity at human CXCR1 expressed in HEK293 cells assessed as inhibition of CXCL8-induced intracellular Ca2+ release by fluorescence based... | J Med Chem 57: 8378-97 (2014) Article DOI: 10.1021/jm500827t BindingDB Entry DOI: 10.7270/Q2FX7C22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
fMet-Leu-Phe receptor (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems Curated by ChEMBL | Assay Description Antagonist activity at fMLF receptor in human PMNs assessed as inhibition of fMLF-induced intracellular Ca2+ release by fluorescence based calcium fl... | J Med Chem 57: 8378-97 (2014) Article DOI: 10.1021/jm500827t BindingDB Entry DOI: 10.7270/Q2FX7C22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Platelet activating factor receptor (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems Curated by ChEMBL | Assay Description Antagonist activity at platelet-activating factor receptor in human PMNs assessed as inhibition of PAF-induced intracellular Ca2+ release by fluoresc... | J Med Chem 57: 8378-97 (2014) Article DOI: 10.1021/jm500827t BindingDB Entry DOI: 10.7270/Q2FX7C22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems, Inc. US Patent | Assay Description The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium... | US Patent USRE47267 (2019) BindingDB Entry DOI: 10.7270/Q2GF0WSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems Curated by ChEMBL | Assay Description Antagonist activity at human CXCR2 expressed in HEK293 cells assessed as inhibition of CVCL8-induced [35S]GTPgammaS binding after 60 mins | J Med Chem 57: 8378-97 (2014) Article DOI: 10.1021/jm500827t BindingDB Entry DOI: 10.7270/Q2FX7C22 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 730 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems Curated by ChEMBL | Assay Description Inhibition of CXCR2 (unknown origin) expressed in PathHunter celline by beta-arrestin assay | Bioorg Med Chem Lett 25: 2280-4 (2015) Article DOI: 10.1016/j.bmcl.2015.04.041 BindingDB Entry DOI: 10.7270/Q26Q200G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 356 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems Curated by ChEMBL | Assay Description Inhibition of CXCR2 (unknown origin) transfected with RBL cells | Bioorg Med Chem Lett 25: 2280-4 (2015) Article DOI: 10.1016/j.bmcl.2015.04.041 BindingDB Entry DOI: 10.7270/Q26Q200G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 1 (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 903 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems Curated by ChEMBL | Assay Description Inhibition of CXCR1 (unknown origin) transfected with RBL cells | Bioorg Med Chem Lett 25: 2280-4 (2015) Article DOI: 10.1016/j.bmcl.2015.04.041 BindingDB Entry DOI: 10.7270/Q26Q200G | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems, Inc. US Patent | Assay Description The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium... | US Patent USRE47267 (2019) BindingDB Entry DOI: 10.7270/Q2GF0WSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C-X-C chemokine receptor type 2 (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems, Inc. US Patent | Assay Description The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium... | US Patent USRE47267 (2019) BindingDB Entry DOI: 10.7270/Q2GF0WSH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
C5a anaphylatoxin chemotactic receptor (C5aR) (Homo sapiens (Human)) | BDBM150811 (US8981106, 1 (SX-517) | USRE47267, Compound 1) | PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | >5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Syntrix Biosystems Curated by ChEMBL | Assay Description Antagonist activity at C5a receptor in human PMNs assessed as inhibition of C5a-induced intracellular Ca2+ release by fluorescence based calcium flux... | J Med Chem 57: 8378-97 (2014) Article DOI: 10.1021/jm500827t BindingDB Entry DOI: 10.7270/Q2FX7C22 | |||||||||||
More data for this Ligand-Target Pair |