BDBM150836 US8981106, 25::USRE47267, Compound 25

SMILES: OC(=O)c1cccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1

InChI Key: InChIKey=DGMNFRFRKNNMQE-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 150836   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM150836 (US8981106, 25 | USRE47267, Compound 25) Show SMILES OC(=O)c1cccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1 Show InChI InChI=1S/C20H15FN2O3S/c21-16-5-7-17(8-6-16)23-19(24)15-4-9-18(22-11-15)27-12-13-2-1-3-14(10-13)20(25)26/h1-11H,12H2,(H,23,24)(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a	n/a	37
Syntrix Biosystems, Inc. US Patent					Assay Description An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...				US Patent US8981106 (2015) BindingDB Entry DOI: 10.7270/Q2WW7GC1
					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM150836 (US8981106, 25 | USRE47267, Compound 25) Show SMILES OC(=O)c1cccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1 Show InChI InChI=1S/C20H15FN2O3S/c21-16-5-7-17(8-6-16)23-19(24)15-4-9-18(22-11-15)27-12-13-2-1-3-14(10-13)20(25)26/h1-11H,12H2,(H,23,24)(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Syntrix Biosystems, Inc. US Patent					Assay Description The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...				US Patent USRE47267 (2019) BindingDB Entry DOI: 10.7270/Q2GF0WSH
					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM150836 (US8981106, 25 | USRE47267, Compound 25) Show SMILES OC(=O)c1cccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1 Show InChI InChI=1S/C20H15FN2O3S/c21-16-5-7-17(8-6-16)23-19(24)15-4-9-18(22-11-15)27-12-13-2-1-3-14(10-13)20(25)26/h1-11H,12H2,(H,23,24)(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	2.12E+3	n/a	n/a	n/a	n/a	n/a	n/a
Syntrix Biosystems Curated by ChEMBL					Assay Description Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...				J Med Chem 57: 8378-97 (2014) Article DOI: 10.1021/jm500827t BindingDB Entry DOI: 10.7270/Q2FX7C22
					More data for this Ligand-Target Pair