BDBM150847 US8981106, 36

SMILES: Cc1nc(cs1)-c1ccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)cc1

InChI Key: InChIKey=DHQPDQVRONZHKT-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 150847   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM150847 (US8981106, 36) Show SMILES Cc1nc(cs1)-c1ccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)cc1 Show InChI InChI=1S/C23H18FN3OS2/c1-15-26-21(14-29-15)17-4-2-16(3-5-17)13-30-22-11-6-18(12-25-22)23(28)27-20-9-7-19(24)8-10-20/h2-12,14H,13H2,1H3,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Syntrix Biosystems Curated by ChEMBL					Assay Description Antagonist activity at CXCR2 in human PMNs assessed as inhibition of CXCL1-induced intracellular Ca2+ release by fluorescence based calcium flux assa...				J Med Chem 57: 8378-97 (2014) Article DOI: 10.1021/jm500827t BindingDB Entry DOI: 10.7270/Q2FX7C22
					More data for this Ligand-Target Pair
C-X-C chemokine receptor type 2 (Homo sapiens (Human))	BDBM150847 (US8981106, 36) Show SMILES Cc1nc(cs1)-c1ccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)cc1 Show InChI InChI=1S/C23H18FN3OS2/c1-15-26-21(14-29-15)17-4-2-16(3-5-17)13-30-22-11-6-18(12-25-22)23(28)27-20-9-7-19(24)8-10-20/h2-12,14H,13H2,1H3,(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	37
Syntrix Biosystems, Inc. US Patent					Assay Description An in vitro assay showed inhibition of CXCR2-mediated intracellular calcium release. Briefly, human neutrophils were suspended in HBSS- (without Ca2+...				US Patent US8981106 (2015) BindingDB Entry DOI: 10.7270/Q2WW7GC1
					More data for this Ligand-Target Pair